Browsing by Author "Brañes Yunusic, Jorge Antonio"
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- ItemExpression of teneurins is associated with tumor differentiation and patient survival in ovarian cancer(2017) Graumann, Rebecca; Di Capua, Gabriella A.; Oyarzún Isamitt, Juan Esteban; Vásquez, Marcos A.; Liao, Christine; Brañes Yunusic, Jorge Antonio; Roa, Iván; Casanello Toledo, Paola Cecilia; Corvalán R., Alejandro; Owen, Gareth Ivor; Delgado, Iris; Zangemeister-Wittke, Uwe; Ziegler, Annemarie
- ItemLeptin promotes a more aggressive behavior of ovarian cancer cells : a potential explanation for a worse prognosis in obese ovarian cancer patients(2015) Cuello F., Mauricio; Kato Cardemil, Sumie Rode; Abarzúa Catalán, L.; Delpiano, A.; García, K.; Sanhueza, C.; Ibáñez Cáceres, Carolina; Brañes Yunusic, Jorge Antonio; Castellón E.; Owen, Gareth Ivor; Trigo, C.
- ItemLeptin stimulates migration and invasion and maintains cancer stem-like properties in ovarian cancer cells : an explanation for poor outcomes in obese women(2015) Kato Cardemil, Sumie Rode; Abarzúa Catalán, Lorena; Trigo, César; Delpiano, Ana; Sanhueza, Cristobal; García, Karen; Ibáñez Cáceres, Carolina; Hormazábal, Katherine; Díaz Bórquez, Daniela Aida; Brañes Yunusic, Jorge Antonio; Castellón, Enrique; Bravo, Erasmo; Owen, Gareth Ivor; Cuello F., Mauricio
- ItemTeneurin protein family: an emerging role in human tumorigenesis and drug resistance(2012) Ziegler, Annemarie; Corvalán Rodríguez, Alejandro; Roa, Iván; Brañes Yunusic, Jorge Antonio; Wollscheid, BerndUsing a chemoproteomic strategy, we recently demonstrated the expression of teneurin-2, a transmembrane glycoprotein, in the majority of malignant mesothelioma cell lines. This finding was unexpected since no formally organized evidence existed to implicate teneurins in human malignancy. For this reason, here we provide a comprehensive review on the expression of teneurins in human tumors and cell lines. Current evidence supports the aberrant expression of teneurins in various tumor types, their involvement in cancer-related regulatory networks, and their potential participation in drug resistance. Structural attributes of teneurins could enable the detection of shedded forms in body fluids for clinical applications. (C) 2012 Elsevier Ireland Ltd. All rights reserved.