Browsing by Author "Botnar, René M."

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    Advances in molecular imaging of atherosclerosis and myocardial infarction: shedding new light on in vivo cardiovascular biology
    (2012) Phinikaridou, Alkystis; Andía Kohnenkampf, Marcelo Edgardo; Shah, Ajay M.; Botnar, René M.
    Molecular imaging of the cardiovascular system heavily relies on the development of new imaging probes and technologies to facilitate visualization of biological processes underlying or preceding disease. Molecular imaging is a highly active research discipline that has seen tremendous growth over the past decade. It has broadened our understanding of oncologic, neurologic, and cardiovascular diseases by providing new insights into the in vivo biology of disease progression and therapeutic interventions. As it allows for the longitudinal evaluation of biological processes, it is ideally suited for monitoring treatment response. In this review, we will concentrate on the major accomplishments and advances in the field of molecular imaging of atherosclerosis and myocardial infarction with a special focus on magnetic resonance imaging.
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    Free‐breathing 3D whole‐heart joint T1/T2 mapping and water/fat imaging at 0.55 T
    (2024) Si, Dongyue; Crabb, Michael G.; Kunze, Karl P.; Littlewood, Simon J.; Prieto Vasquez, Claudia Del Carmen; Botnar, René M.
    To develop and validate a highly efficient motion compensated free-breathingisotropic resolution 3D whole-heart joint T 1 /T2 mapping sequence with anatomicalwater/fat imaging at 0.55 T.Methods: The proposed sequence takes advantage of shorter T1 at 0.55 T to acquirethree interleaved water/fat volumes with inversion-recovery preparation, no prepara-tion, and T 2 preparation, respectively. Image navigators were used to facilitate nonrigidmotion-compensated image reconstruction. T1 and T2 maps were jointly calculated bya dictionary matching method. Validations were performed with simulation, phantom,and in vivo experiments on 10 healthy volunteers and 1 patient. The performance ofthe proposed sequence was compared with conventional 2D mapping sequences includ-ing modified Look-Locker inversion recovery and T2 -prepared balanced steady-SSFPsequence.Results: The proposed sequence has a good T1 and T2 encoding sensitivity in simula-tion, and excellent agreement with spin-echo reference T 1 and T2 values was observedin a standardized T1 /T2 phantom (R2 = 0.99). In vivo experiments provided good-qualityco-registered 3D whole-heart T1 and T2 maps with 2-mm isotropic resolution in ashort scan time of about 7 min. For healthy volunteers, left-ventricle T1 mean andSD measured by the proposed sequence were both comparable with those of modi-fied Look-Locker inversion recovery (640 ± 35 vs. 630 ± 25 ms [p = 0.44] and 49.9 ± 9.3vs. 54.4 ± 20.5 ms [p = 0.42]), whereas left-ventricle T2 mean and SD measured by theproposed sequence were both slightly lower than those of T2 -prepared balanced SSFP(53.8 ± 5.5 vs. 58.6 ± 3.3 ms [p < 0.01] and 5.2 ± 0.9 vs. 6.1 ± 0.8 ms [p = 0.03]). MyocardialT 1 and T2 in the patient measured by the proposed sequence were in good agreementwith conventional 2D sequences and late gadolinium enhancement.Conclusion: The proposed sequence simultaneously acquires 3D whole-heart T1 and T2mapping with anatomical water/fat imaging at 0.55 T in a fast and efficient 7-min scan.Further investigation in patients with cardiovascular disease is now warranted