Browsing by Author "Bohmwald Prieto, Karen"

Now showing 1 - 17 of 17
  • Thumbnail Image
    Item
    Central nervous system alterations caused by infection with the human respiratory syncytial virus
    (2014) Bohmwald Prieto, Karen; Espinoza Véliz, Janyra Alejandra; González Muñoz, Pablo Alberto; Bueno Ramírez, Susan; Riedel, C.; Kalergis Parra, Alexis Mikes
  • Thumbnail Image
    Item
    Contribution of IDO to human respiratory syncytial virus infection
    (2019) Benavente, Felipe M.; Soto Ramírez, Jorge Andrés; Pizarro Ortega, Magdalena S.; Bohmwald Prieto, Karen; González, Pablo A.; Bueno Ramírez, Susan; Kalergis Parra, Alexis Mikes
  • Thumbnail Image
    Item
    Contribution of NKT cells to the immune response and pathogenesis triggered by respiratory viruses
    (2020) Rey Jurado, E.; Bohmwald Prieto, Karen; Gálvez, N. M. S.; Becerra, D.; Porcelli, S. A.; Carreño Márquez, Leandro Javier; Kalergis Parra, Alexis Mikes
  • Thumbnail Image
    Item
    Contribution of pro-inflammatory molecules induced by respiratory virus infections to neurological disorders
    (MDPI AG, 2021) Bohmwald Prieto, Karen; Andrade Parra, Catalina Andrea; Kalergis Parra, Alexis Mikes
    Neurobehavioral alterations and cognitive impairment are common phenomena that represent neuropsychiatric disorders and can be triggered by an exacerbated immune response against pathogens, brain injury, or autoimmune diseases. Pro-inflammatory molecules, such as cytokines and chemokines, are produced in the brain by resident cells, mainly by microglia and astrocytes. Brain infiltrating immune cells constitutes another source of these molecules, contributing to an impaired neurological synapse function, affecting typical neurobehavioral and cognitive performance. Currently, there is increasing evidence supporting the notion that behavioral alterations and cognitive impairment can be associated with respiratory viral infections, such as human respiratory syncytial virus, influenza, and SARS-COV-2, which are responsible for endemic, epidemic, or pandemic outbreak mainly in the winter season. This article will review the brain0s pro-inflammatory response due to infection by three highly contagious respiratory viruses that are the leading cause of acute respiratory illness, morbidity, and mobility in infants, immunocompromised and elderly population. How these respiratory viral pathogens induce increased secretion of pro-inflammatory molecules and their relationship with the alterations at a behavioral and cognitive level will be discussed.
  • Thumbnail Image
    Item
    Differential expression profile of CXCR3 splicing variants is associated with thyroid neoplasia. Potential role in papillary thyroid carcinoma oncogenesis?
    (2018) Urra, Soledad; Fischer, Martin C.; Martinez, Jose R.; Veliz, Loreto; Orellana, Paulina; Solar González, Antonieta Alejandra; Bohmwald Prieto, Karen; Kalergis Parra, Alexis Mikes; Riedel, Claudia; Corvalán R., Alejandro; Roa Strauch, Juan Carlos Enrique; Fuentealba, Rodrigo; Cáceres, C. Joaquín; López Lastra, Marcelo Andrés; León Ramírez, Augusto; Droppelmann, Nicolás; Gonzalez, Hernan E.
  • Thumbnail Image
    Item
    Functional Impairment of Mononuclear Phagocyte System by the Human Respiratory Syncytial Virus
    (2017) Bohmwald Prieto, Karen; Espinoza, J.; Pulgar, R.; Jara, E.; Kalergis Parra, Alexis Mikes
  • Thumbnail Image
    Item
    Gestational Hypothyroxinemia Imprints a Switch in the Capacity of Astrocytes and Microglial Cells of the Offspring to React in Inflammation
    (2018) Opazo, María C.; González, Pablo A.; Flores, Betsi D.; Venegas, Luis F.; Albornoz, Eduardo A.; Cisternas, Pablo; Bohmwald Prieto, Karen; Nieto Pacheco, Pamela Andrea; Bueno Ramírez, Susan; Kalergis Parra, Alexis Mikes; Riedel, Claudia A.
  • Thumbnail Image
    Item
    Human Respiratory Syncytial Virus: Infection and Pathology
    (2016) Bohmwald Prieto, Karen; Espinoza Véliz, Janyra Alejandra; Rey Jurado, Emma; Gómez Johnson, Roberto Sebastian; González Muñoz, Pablo Alberto; Bueno Ramírez, Susan; Riedel, Claudia A.; Kalergis Parra, Alexis Mikes
    The human respiratory syncytial virus (hRSV) is by far the major cause of acute lower respiratory tract infections (ALRTIs) worldwide in infants and children younger than 2 years. The overwhelming number of hospitalizations due to hRSV-induced ALRTI each year is due, at least in part, to the lack of licensed vaccines against this virus. Thus, hRSV infection is considered a major public health problem and economic burden in most countries. The lung pathology developed in hRSV-infected individuals is characterized by an exacerbated proinflammatory and unbalanced Th2-type immune response. In addition to the adverse effects in airway tissues, hRSV infection can also cause neurologic manifestations in the host, such as seizures and encephalopathy. Although the origins of these extrapulmonary symptoms remain unclear, studies with patients suffering from neurological alterations suggest an involvement of the inflammatory response against hRSV. Furthermore, hRSV has evolved numerous mechanisms to modulate and evade the immune response in the host. Several studies have focused on elucidating the interactions between hRSV virulence factors and the host immune system, to rationally design new vaccines and therapies against this virus. Here, we discuss about the infection, pathology, and immune response triggered by hRSV in the host.
  • Thumbnail Image
    Item
    Impaired learning resulting from Respiratory Syncytial Virus infection
    (2013) Espinoza Véliz, Janyra Alejandra; Bohmwald Prieto, Karen; Céspedes, Pablo F.; Gómez, Roberto S.; Riquelme, Sebastián A.; Cortés, Claudia M.; Valenzuela, Javier A.; Sandoval, Rodrigo A.; Bueno Ramírez, Susan; Kalergis Parra, Alexis Mikes
  • Thumbnail Image
    Item
    Imprinting of maternal thyroid hormones in the offspring.
    (2017) Opazo, M.; Haensgen, H.; Bohmwald Prieto, Karen; Venegas, L.; Boudin, H.; Elorza, A.; Simon, F.; Fardella B., Carlos; Bueno Ramírez, Susan; Kalergis Parra, Alexis Mikes; Riedel, C.
  • Thumbnail Image
    Item
    Inflammatory damage on respiratory and nervous systems due to hRSV infection
    (2015) Bohmwald Prieto, Karen; Espinoza Véliz, Janyra Alejandra; Becerra, D.; Rivera, K.; Lay, M.; Bueno Ramírez, Susan; Riedel, C.; Kalergis Parra, Alexis Mikes
  • Thumbnail Image
    Item
    Lung pathology due to hRSV infection impairs blood–brain barrier permeability enabling astrocyte infection and a long-lasting inflammation in the CNS
    (2021) Bohmwald Prieto, Karen; Soto Ramírez, Jorge Andrés; Andrade Parra, Catalina Andrea; Fernández Fierro, Ayleen Lorena; Espinoza Véliz, Janyra Alejandra; Rios Raggio, Mariana; Eugenin, E. A.; González Muñoz, Pablo Alberto; Opazo, M. C.; Kalergis Parra, Alexis Mikes
  • Thumbnail Image
    Item
    Modulation of host adaptive immunity by hRSV proteins
    (2014) Espinoza Véliz, Janyra Alejandra; Bohmwald Prieto, Karen; Cespedes, P.; Riedel, C.; Bueno Ramírez, Susan; Kalergis Parra, Alexis Mikes
  • Thumbnail Image
    Item
    Neurotrophin Signaling Impairment by Viral Infections in the Central Nervous System
    (SPRINGER INTERNATIONAL PUBLISHING AG, 2022) Bohmwald Prieto, Karen; Andrade Parra, Catalina Andrea; Mora Rivera, Valentina Paz; Muñoz Flores, José Tomas; Ramírez Inostroza, Robinson Alonso; Rojas Hernández, María Fernanda; Kalergis Parra, Alexis Mikes
    Neurotrophins, such as nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin 3 (NT-3), NT-4, and NT-5, are proteins involved in several important functions of the central nervous system. The activation of the signaling pathways of these neurotrophins, or even by their immature form, pro-neurotrophins, starts with their recognition by cellular receptors, such as tropomyosin receptor kinase (Trk) and 75 kD NT receptors (p75NTR). The Trk receptor is considered to have a high affinity for attachment to specific neurotrophins, while the p75NTR receptor has less affinity for attachment with neurotrophins. The correct functioning of these signaling pathways contributes to proper brain development, neuronal survival, and synaptic plasticity. Unbalanced levels of neurotrophins and pro-neurotrophins have been associated with neurological disorders, illustrating the importance of these molecules in the central nervous system. Furthermore, reports have indicated that viruses can alter the normal levels of neurotrophins by interfering with their signaling pathways. This work discusses the importance of neurotrophins in the central nervous system, their signaling pathways, and how viruses can affect them.
  • Thumbnail Image
    Item
    Potenciales consecuencias neurocognitivas de infección por virus respiratorio sincicial humano
    (2016) Flores, Juan Carlos; Bohmwald Prieto, Karen; Espinoza Véliz, Janyra Alejandra; Jara, Cristina; Peña, Marcela; Hoyos Bachiloglu, Rodrigo Andrés; Iturriaga, Carolina; Kalergis Parra, Alexis Mikes; Borzutzky Schachter, Arturo
  • Thumbnail Image
    Item
    Respiratory Syncytial Virus: Pathology, therapeutic drugs and prophylaxis
    (2014) Gómez Johnson, Roberto Sebastian; Bohmwald Prieto, Karen; Bueno Ramírez, Susan
  • Thumbnail Image
    Item
    Severe respiratory disease caused by human respiratory syncytial virus impairs language learning during early infancy
    (2020) Peña, Marcela; Jara González, María Cristina; Flores, Juan Carlos; Hoyos Bachiloglu, Rodrigo Andrés; Medina Lainez, Mariana Andrea; Carcey Rivera, Javier Ignacio; Espinoza Véliz, Janyra Alejandra; Bohmwald Prieto, Karen; Kalergis Parra, Alexis Mikes; Borzutzky Schachter, Arturo; Iturriaga, C.