Browsing by Author "Boccardo, Enrique"

Now showing 1 - 3 of 3
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    Interplay between Epstein-Barr virus infection and environmental xenobiotic exposure in cancer
    (2021) Aguayo González, Francisco; Boccardo, Enrique; Corvalán R., Alejandro; Calaf, Gloria M.; Blanco, Rancés
    Abstract Epstein-Barr virus (EBV) is a herpesvirus associated with lymphoid and epithelial malignancies. Both B cells and epithelial cells are susceptible and permissive to EBV infection. However, considering that 90% of the human population is persistently EBV-infected, with a minority of them developing cancer, additional factors are necessary for tumor development. Xenobiotics such as tobacco smoke (TS) components, pollutants, pesticides, and food chemicals have been suggested as cofactors involved in EBV-associated cancers. In this review, the suggested mechanisms by which xenobiotics cooperate with EBV for carcinogenesis are discussed. Additionally, a model is proposed in which xenobiotics, which promote oxidative stress (OS) and DNA damage, regulate EBV replication, promoting either the maintenance of viral genomes or lytic activation, ultimately leading to cancer. Interactions between EBV and xenobiotics represent an opportunity to identify mechanisms by which this virus is involved in carcinogenesis and may, in turn, suggest both prevention and control strategies for EBV-associated cancers.
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    Three Prime Repair Exonuclease 1 (TREX1) expression correlates with cervical cancer cells growth in vitro and disease progression in vivo
    (2019) Prati, Bruna; Abjaude, Walason da Silva; Termini, Lara; Morale, Mirian; Herbster, Suellen; Aguayo González, Francisco; Longatto-Filho, Adhemar; Nunes, Rafaella Almeida Lima; Córdoba Camacho, Lizeth Carolina; Rabelo-Santos, Silvia Helena; Zeferino, Luiz Carlos; Boccardo, Enrique
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    Upregulation of PIR gene expression induced by human papillomavirus E6 and E7 in epithelial oral and cervical cells
    (2017) Carrillo, Diego; Muñoz, Juan P.; Huerta, Hernán; Leal, Gabriel; Corvalán R., Alejandro; León, Oscar; Calaf, Gloria M.; Urzúa, Ulises; Boccardo, Enrique; Aguayo González, Francisco