Browsing by Author "Billeke, P."
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- ItemFunctional cortical network in alpha band correlates with social bargaining(2014) Billeke, P.; Zamorano, F.; Chavez, M.; Cosmelli, Diego; Aboitiz, Francisco
- ItemIntra-individual response variability assessed by ex-Gaussian analysis may be a new endophenotype for attention-deficit/hyperactivity disorder(2015) Henriquez-Henriquez, M. P.; Billeke, P.; Henriquez, H.; Zamorano, F. J.; Rothhammer, F.; Aboitiz, FranciscoIntra-individual variability of response times (RTisv) is considered as potential endophenotype for attentional deficit/hyperactivity disorder (ADHD). Traditional methods for estimating RTisv lose information regarding response times (RTs) distribution along the task, with eventual effects on statistical power. Ex-Gaussian analysis captures the dynamic nature of RTisv, estimating normal and exponential components for RT distribution, with specific phenomenological correlates. Here, we applied ex-Gaussian analysis to explore whether intra-individual variability of RTs agrees with criteria proposed by Gottesman and Gould for endophenotypes. Specifically, we evaluated if normal and/or exponential components of RTs may (a) present the stair-like distribution expected for endophenotypes (ADHD > siblings > typically developing children (TD) without familiar history of ADHD) and (b) represent a phenotypic correlate for previously described genetic risk variants. This is a pilot study including 55 subjects (20 ADHD-discordant sibling-pairs and 15 TD children), all aged between 8 and 13 years. Participants resolved a visual Go/Nogo with 10% Nogo probability. Ex-Gaussian distributions were fitted to individual RT data and compared among the three samples. In order to test whether intra-individual variability may represent a correlate for previously described genetic risk variants, VNTRs at DRD4 and SLC6A3 were identified in all sibling-pairs following standard protocols. Groups were compared adjusting independent general linear models for the exponential and normal components from the ex-Gaussian analysis. Identified trends were confirmed by the non-parametric Jonckheere–Terpstra test. Stair-like distributions were observed for μ (p = 0.036) and σ (p = 0.009). An additional “DRD4-genotype” × “clinical status” interaction was present for τ (p = 0.014) reflecting a possible severity factor. Thus, normal and exponential RTisv components are suitable as ADHD endophenotypes.
- ItemLateral prefrontal activity as a compensatory strategy for defcits of cortical processing in Attention Deficit Hyperactivity Disorder(2017) Zamorano, F.; Billeke, P.; Kausel Kamp, Leonie Margarita; Larraín Correa, Juan Agustín; Stecher, X.; Hurtado, J.; López Hernández, Vladimir; Carrasco, X.; Aboitiz, Francisco
- ItemLateral Prefrontal Theta Oscillations Reflect Proactive Cognitive Control Impairment in Males With Attention Deficit Hyperactivity Disorder(2020) Zamorano, F.; Kausel Kamp, Leonie Margarita; Albornoz, C.; Lavin Tapia, Claudio Sebastian; Figueroa Vargas, A.; Stecher, X.; Aragon Caqueo, D.; Carrasco, X.; Aboitiz, Francisco; Billeke, P.
- ItemNeural Dynamics of Improved Bimodal Attention and Working Memory in Musically Trained Children(2020) Kausel Kamp, Leonie Margarita; Zamorano, F.; Billeke, P.; Sutherland , Mary Elizabeth; Larrain Valenzuela, J.; Stecher, X.; Schlaug, G.; Aboitiz, Francisco
- ItemSocial cognition in schizophrenia : from social stimuli processing to social engagement(2013) Billeke, P.; Aboitiz, Francisco
- ItemTemporal constraints of behavioral inhibition: relevance of inter-stimulus interval in a Go-Nogo task(2014) Zamorano, F.; Billeke, P.; Hurtado, J. M.; López Hernández, Vladimir; Carrasco, X.; Ossandón, Tomás; Aboitiz, Francisco