Browsing by Author "Armisen, Ricardo"
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- ItemChilean Gastric Cancer Task Force : a study protocol to obtain a clinical and molecular classification of a cohort of gastric cancer patients(2018) Owen, Gareth Ivor; Pinto, Mauricio P.; Retamal, Ignacio N.; Fernández, María F.; Cisternas, Betzabe; Mondaca Contreras, Sebastián Patricio; Sánchez Rojel, César Giovanni; Galindo A., Héctor; Nervi, Bruno; Ibáñez Cáceres, Carolina; Acevedo Claros, Francisco Nicolás; Madrid Arenas, Jorge; Peña, José; Bravo Castillo, María Loreto; Maturana, María, José; Córdova Delgado, Miguel; Romero, Diego; De la Jara, Nathaly; Torres Montes, Paula Javiera; Rodríguez Fernández, María; Espinoza Sepúlveda, Manuel Antonio; Balmaceda, Carlos; Freire, Matías; Gárate Calderón, Valentina; Crovari Eulufi, Fernando; Jiménez Fonseca, Paula; Carmona Bayonas, Alberto; Zwenger, Ariel; Armisen, Ricardo; Corválan, Alejandro H.; Garrido Salvo, Marcelo; Owen, Gareth Ivor; Pinto, Mauricio P.; Retamal, Ignacio N.; Fernández, María F.; Cisternas, Betzabe; Mondaca, Sebastián; Sánchez Rojel, César Giovanni; Galindo Aranibar, Héctor Gonzalo; Nervi, Bruno; Ibáñez Cáceres, Carolina; Acevedo Claros, Francisco Nicolás; Madrid, Jorge; Peña, José; Bravo, María, Loreto; Maturana, María, José; Córdova Delgado, Miguel; Romero, Diego; De la Jara, Nathaly; Torres, Javiera; Rodríguez Fernández, María; Espinoza Sepúlveda, Manuel Antonio; Balmaceda, Carlos; Freire, Matías; Gárate Calderón, Valentina; Crovari Eulufi, Fernando; Jiménez Fonseca, Paula; Carmona Bayonas, Alberto; Zwenger, Ariel; Armisen, Ricardo; Corválan, Alejandro H.; Garrido, Marcelo
- ItemThe Ski Protein is Involved in the Transformation Pathway of Aurora Kinase A(WILEY, 2016) Rivas, Solange; Armisen, Ricardo; Rojas, Diego A.; Maldonado, Edio; Huerta, Hernan; Tapia, Julio C.; Espinoza, Jaime; Colombo, Alicia; Michea, Luis; Hayman, Michael J.; Marcelain, KatherineOncogenic kinase Aurora A (AURKA) has been found to be overexpresed in several tumors including colorectal, breast, and hematological cancers. Overexpression of AURKA induces centrosome amplification and aneuploidy and it is related with cancer progression and poor prognosis. Here we show that AURKA phosphorylates in vitro the transcripcional co-repressor Ski on aminoacids Ser326 and Ser383. Phosphorylations on these aminoacids decreased Ski protein half-life. Reduced levels of Ski resulted in centrosomes amplification and multipolar spindles formation, same as AURKA overexpressing cells. Importantly, overexpression of Ski wild type, but not S326D and S383D mutants inhibited centrosome amplification and cellular transformation induced by AURKA. Altogether, these results suggest that the Ski protein is a target in the transformation pathway mediated by the AURKA oncogene. (C) 2015 Wiley Periodicals, Inc.