Browsing by Author "Anegon, Ignacio"

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    Carbon monoxide exposure improves immune function in lupus-prone mice
    (2013) Mackern Oberti, Juan Pablo; Llanos Muñoz, Carolina; Carreño Márquez, Leandro Javier; Riquelme, Sebastián A.; Jacobelli, Sergio H.; Anegon, Ignacio; Kalergis Parra, Alexis Mikes
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    Immunoregulatory Properties of Heme Oxygenase-1
    (2011) Blancou, Philippe; Tardif, Virginie; Simon, Thomas; Rémy, Séverine; Carreño, Leandro; Kalergis, Alexis M.; Anegon, Ignacio
    Heme oxygenase-1 (HO-1) is one of the three isoforms of the heme oxygenase enzyme that catabolyzes the degradation of heme into biliverdin with the production of free iron and CO. HO-1 is induced by its substrate and by other stimuli, including agents involved in oxidative stress and proinflammatory cytokines as well as several anti-inflammatory stimuli. A growing body of evidence points toward the capacity of this molecule to inhibit immune reactions and the pivotal role of HO-1 in inflammatory diseases. We will first review the physiological role of HO-1 as determined by the analysis of HO-1-deficient individuals. This will be followed by an examination of the effect of HO-1 within immunopathological contexts such as immune disorders (autoimmunity and allergy) or infections. A section will be devoted to the use of an HO-1 inducer as an immunosuppressive molecule in transplantation. Finally, we will review the molecular basis of HO-1 actions on different immune cells.