Browsing by Author "Alvarez, Ana M."

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    Invasive fungal infections in children with cancer and severe aplastic anemia in nine hospitals from PINDA Network, Chile. 2016-2020
    (2023) Gutierrez, Valentina; Contardo, Veronica; de la Maza, Veronica; Claverie, Ximena; Salgado, Carmen; Zubieta, Marcela; Silva, Beatriz; Torres, Juan P.; Greppi, Claudia; Venegas, Marcela; Martinez, Daniela; Alvarez, Ana M.; Labrana, Yenis; Diaz, Paulina; Ducasse, Karen; Inostroza, Tamara; Cordova, Marcela; Santolaya, Maria E.
    Background: Invasive fungal infections (IFIs) are an important cause of morbidity and mortality in pediatric oncology patients and severe aplastic anemia (SAA). Aim: To describe the epidemiology of IFI from 2016 to 2020 in children with cancer and SAA to assess the indication of antifungal prophylaxis. Methods: Multicenter, retrospective study of IFIs in pediatric oncology patients and SAA. Probable and proven IFIs were included. Results: Over the 5-year period, 57 IFIs were found, median age 9 years, 70% were proven and 30% were probable. Yeast infections were 42% and mold infections 56%. The most frequent infection sites were lung 38%, blood 36% and rhinosinusal 21%. The total IFI frequency was 5.4%, 21% in SAA, 10% in acute myeloid leukemia (AML), 6.9% in relapsed AML, 5.4% in relapsed acute lymphoblastic leukemia (ALL), 3.8% in ALL. Mold infections were predominant in AML, relapsed AML, and SAA. IFIs mortality was 11%. Conclusion: Frequency of IFI was consistent with the literature. We strongly recommend antifungal prophylaxis against mold infections in patients with SAA, AML, and relapsed AML. Would consider in high risk ALL relapse in induction chemotherapy.
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    Risk Factors Associated With Invasive Fungal Disease in Children With Cancer and Febrile Neutropenia A Prospective Multicenter Evaluation
    (LIPPINCOTT WILLIAMS & WILKINS, 2010) Villarroel, Milena; Aviles, Carmen L.; Silva, Pamela; Guzman, Ana M.; Poggi, Helena; Alvarez, Ana M.; Becker, Ana; O'Ryan, Miguel; Salgado, Carmen; Topelberg, Santiago; Tordecilla, Juan; Varas, Monica; Viviani, Tamara; Zubieta, Marcela; Santolaya, Maria E.
    Background: Empiric antifungal treatment has become standard of care in children with cancer and prolonged fever and febrile neutropenia (FN), with the downside that it leads to significant over treatment. We characterized epidemiologic, clinical, and laboratory features of invasive fungal disease (IFD) in children with cancer and FN with the aim to identify risk factors for IFD that can aid in better selecting children who require antifungal treatment.