Browsing by Author "Alvarado, Juan"

Now showing 1 - 8 of 8
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    Allowing New Opportunities in Advanced Laparoscopy Training Using a Full High-Definition Training Box
    (2016) Achurra Tirado, Pablo; Lagos, Antonia; Ávila, Rubén; Tejos, Rodrigo; Buckel, Erwin; Alvarado, Juan; Boza, Camilo; Jarufe Cassis, Nicolás; Varas, Julián
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    Bariatric surgery in 1119 patients with preoperative body mass index < 35 (kg/m(2)) : results at 1 year
    (2015) Maiz, Cristobal; Alvarado, Juan; Quezada Sanhueza, Nicolás; Salinas, Jose; Funke, Ricardo
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    ¿Cuál es el rol de la proteína C activada en el tratamiento de la sepsis?
    (2016) Alvarado, Juan; Castro López, Ricardo
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    Effectiveness of Learning Advanced Laparoscopic Skills in a Brief Intensive Laparoscopy Training Program
    (2015) Castillo, Richard; Buckel, Erwin; Leon, Felipe; Varas, Julián; Alvarado, Juan; Achurra Tirado, Pablo; Aggarwal, Rajesh; Jarufe Cassis, Nicolás; Boza, Camilo
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    Gallbladder Cancer Risk and Indigenous South American Mapuche Ancestry: Instrumental Variable Analysis Using Ancestry-Informative Markers
    (2023) Zollner, Linda; Boekstegers, Felix; Barahona Ponce, Carol; Scherer, Dominique; Marcelain, Katherine; Gárate-Calderón, Valentina; Waldenberger, Melanie; Morales Mejías, Erik; Rojas, Armando; Muñoz, César; Retamales, Javier; Toro, Gonzalo De; Vera Kortmann, Allan; Barajas, Olga; Rivera, María Teresa; Cortés, Analía; Loader, Denisse; Saavedra, Javiera; Gutiérrez, Lorena; Ortega, Alejandro; Bertrán, María Enriqueta; Bartolotti, Leonardo; Gabler, Fernando; Campos, Mónica; Alvarado, Juan; Moisán, Fabricio; Spencer, María Loreto; Nervi Nattero, Bruno; Carvajal-Hausdorf, Daniel; Losada, Héctor; Almau, Mauricio; Fernández, Plinio; Olloquequi, Jordi; Carter, Alice R.; Miquel P., Juan Francisco; Bustos, Bernabé I.; Fuentes Guajardo, Macarena; Gonzalez-Jose, Rolando; Bortolini, Maria Cátira; Acuña-Alonzo, Victor; Gallo, Carla; Ruiz Linares, Andrés; Rothhammer, Francisco; Bermejo, Justo Lorenzo
    A strong association between the proportion of indigenous South American Mapuche ancestry and the risk of gallbladder cancer (GBC) has been reported in observational studies. Chileans show the highest incidence of GBC worldwide, and the Mapuche are the largest indigenous people in Chile. We set out to assess the confounding-free effect of the individual proportion of Mapuche ancestry on GBC risk and to investigate the mediating effects of gallstone disease and body mass index (BMI) on this association. Genetic markers of Mapuche ancestry were selected based on the informativeness for assignment measure, and then used as instrumental variables in two-sample Mendelian randomization analyses and complementary sensitivity analyses. Results suggested a putatively causal effect of Mapuche ancestry on GBC risk (inverse variance-weighted (IVW) risk increase of 0.8% per 1% increase in Mapuche ancestry proportion, 95% CI 0.4% to 1.2%, p = 6.7 × 10−5) and also on gallstone disease (3.6% IVW risk increase, 95% CI 3.1% to 4.0%), pointing to a mediating effect of gallstones on the association between Mapuche ancestry and GBC. In contrast, the proportion of Mapuche ancestry showed a negative effect on BMI (IVW estimate −0.006 kg/m2, 95% CI −0.009 to −0.003). The results presented here may have significant implications for GBC prevention and are important for future admixture mapping studies. Given that the association between the individual proportion of Mapuche ancestry and GBC risk previously noted in observational studies appears to be free of confounding, primary and secondary prevention strategies that consider genetic ancestry could be particularly efficient.
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    Programa pionero de simulación en sutura para estudiantes de medicina de pregrado
    (2015) Alvarado, Juan; Henríquez R., Juan Pablo; Castillo R., Richard; Sosa B., Javiera; León F., Felipe; Varas, Julián; Camus Appuhn, Mauricio Gonzalo; Riquelme Pérez, Arnoldo; Crovari Eulufi, Fernando; Martínez Castillo, Jorge; Boza, Camilo; Jarude C., Nicolás; Alvarado, Juan; Henríquez R., Juan Pablo; Castillo R., Richard; Sosa B., Javiera; León F., Felipe; Varas, Julián; Camus Appuhn, Mauricio Gonzalo; Riquelme Pérez, Arnoldo; Crovari Eulufi, Fernando; Martínez Castillo, Jorge; Boza, Camilo; Jarude C., Nicolás
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    Subcutaneous Lipoatrophy and Skin Depigmentation Secondary to TMJ Intra-Articular Corticosteroid Injection
    (2017) Skarmeta, Nicolás Patricio; Hormazábal N., Fernando; Alvarado, Juan; Rodríguez, Ana Maria
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    Validation of a Visual-Spatial Secondary Task to Assess Automaticity in Laparoscopic Skills
    (2018) Castillo, Richard; Alvarado, Juan; Moreno, Pablo; Billeke, Pablo; Martinez, Carlos; Varas, Julian; Jarufe Cassis, Nicolás