Browsing by Author "Altermatt, Fernando"
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- ItemAcquiring skills in malignant hyperthermia crisis management: comparison of high-fidelity simulation versus computer-based case study(2018) Mejia, Vilma; Gonzalez, Carlos; Delfino, Alejandro; Altermatt, Fernando; Corvetto Aqueveque, Marcia Antonia; Mejia, Vilma; Gonzalez, Carlos; Delfino, Alejandro; Altermatt, Fernando; Corvetto Aqueveque, Marcia Antonia
- ItemBiomechanical analysis of expert anesthesiologists and novice residents performing a simulated central venous access procedure(2021) Villagrán Gutiérrez, Ignacio Andrés; Moënne-Loccoz, Cristobal; Aguilera Siviragol, Victoria Ignacia; Garcia, Vicente; Reyes, Jose Tomas; Rodriguez, Sebastian; Miranda Mendoza, Constanza; Altermatt, Fernando; Fuentes López, Eduardo; Delgado Bravo, Mauricio Antonio; Neyem, AndrésBackground Central venous access (CVA) is a frequent procedure taught in medical residencies. However, since CVA is a high-risk procedure requiring a detailed teaching and learning process to ensure trainee proficiency, it is necessary to determine objective differences between the expert’s and the novice’s performance to guide novice practitioners during their training process. This study compares experts’ and novices’ biomechanical variables during a simulated CVA performance. Methods Seven experts and seven novices were part of this study. The participants’ motion data during a CVA simulation procedure was collected using the Vicon Motion System. The procedure was divided into four stages for analysis, and each hand’s speed, acceleration, and jerk were obtained. Also, the procedural time was analyzed. Descriptive analysis and multilevel linear models with random intercept and interaction were used to analyze group, hand, and stage differences. Results There were statistically significant differences between experts and novices regarding time, speed, acceleration, and jerk during a simulated CVA performance. These differences vary significantly by the procedure stage for right-hand acceleration and left-hand jerk. Conclusions Experts take less time to perform the CVA procedure, which is reflected in higher speed, acceleration, and jerk values. This difference varies according to the procedure’s stage, depending on the hand and variable studied, demonstrating that these variables could play an essential role in differentiating between experts and novices, and could be used when designing training strategies.
- ItemBoundary integral formulation and semi-implicit scheme coupling for modeling cells under electrical stimulation(2017) Henríquez F.; Jerez Hanckes, Carlos F.; Altermatt, Fernando
- ItemBringing clinical simulation into an Anesthesia residency training program in a university hospital. Participants' acceptability assessment(2013) Corvetto Aqueveque, Marcia Antonia; Bravo, M. P.; Montana, R. A.; Altermatt, Fernando; Delfino, Alejandro; Corvetto Aqueveque, Marcia Antonia; Bravo, M. P.; Montana, R. A.; Altermatt, Fernando; Delfino, AlejandroIntroduction Clinical simulation is currently an integral part of the curriculum of the Anesthesiology residency programs in other countries. We aimed to describe and evaluate the insertion of simulation in an anesthesia residency training program. Methods Activities feasible to be used for training in a simulated environment were classified into 2 modules: workshops for technical skills conducted with first year residents, and high fidelity simulation scenarios performed with second and third year residents. After each activity, and using an anonymous questionnaire, residents assessed their satisfaction and objectives accomplished. Results A total of 18 activities: 6 skills workshops and 12 high fidelity scenarios were assessed. A total of 206 questionnaires were analyzed, corresponding to 41 residents. Almost all (96%) of respondents agreed or strongly agreed that workshops met the objectives and should be mandatory in the anesthesia curriculum; however, 11% agreed that the activity caused anxiety and/or nervousness. The high fidelity scenarios were considered realistic and consistent with the objectives by 97% of residents, and 42% felt that workshops caused anxiety and/or nervousness. Conclusions The inclusion of simulation has been well accepted by the residents. The activities have been described as realistic, and limited to the objectives, essential points in adult education, as according to Kolb's learning model this is associated with profound, useful and long lasting knowledge.Introduction Clinical simulation is currently an integral part of the curriculum of the Anesthesiology residency programs in other countries. We aimed to describe and evaluate the insertion of simulation in an anesthesia residency training program. Methods Activities feasible to be used for training in a simulated environment were classified into 2 modules: workshops for technical skills conducted with first year residents, and high fidelity simulation scenarios performed with second and third year residents. After each activity, and using an anonymous questionnaire, residents assessed their satisfaction and objectives accomplished. Results A total of 18 activities: 6 skills workshops and 12 high fidelity scenarios were assessed. A total of 206 questionnaires were analyzed, corresponding to 41 residents. Almost all (96%) of respondents agreed or strongly agreed that workshops met the objectives and should be mandatory in the anesthesia curriculum; however, 11% agreed that the activity caused anxiety and/or nervousness. The high fidelity scenarios were considered realistic and consistent with the objectives by 97% of residents, and 42% felt that workshops caused anxiety and/or nervousness. Conclusions The inclusion of simulation has been well accepted by the residents. The activities have been described as realistic, and limited to the objectives, essential points in adult education, as according to Kolb's learning model this is associated with profound, useful and long lasting knowledge.
- ItemClinical Research Ethics: Critical and Qualitative Analysis of Facilitators and Barriers(2020) Valera, Luca; González, Karla; Ramos, Paulina; Altermatt, FernandoTo analyze the ethical challenges dealing with clinical research, we carried out a systematic review of the literature and qualitative research, determining facilitators, barriers, and ethical paradigms perceived by Chilean clinical researchers. Through the analysis of the literature, we identified the main ethical challenges involved “in” clinical research (hic et nunc) and those that arise “from” clinical research itself (ex post). Semi-structured interviews showed four critical knots associated with clinical research (founding, legislation, multi-center research, and the relationship with regulatory entities), together with facilitating aspects and barriers when implementing researches.
- ItemComplicaciones cardiopulmonares asociadas a Propofol versus sedación tradicional para procedimientos endoscópicos digestivos en adultos : revisión sistemática y metaanálisis de estudios clínicos randomizados (ECR)(2016) Carmona B., Javiera; Auad A., Hernán; Altermatt, Fernando; Dagnino Sepúlveda, Jorge; Carmona B., Javiera; Auad A., Hernán; Altermatt, Fernando; Dagnino Sepúlveda, Jorge
- ItemControl-flow analysis of procedural skills competencies in medical training through process mining(2020) Fuente Sanhueza, René Francisco de la; Fuentes Henríquez, Ricardo Sergio; Muñoz Gama, Jorge; Riquelme Pérez, Arnoldo; Altermatt, Fernando; Pedemonte Trewhela, Juan Cristóbal; Corvetto Aqueveque, Marcia Antonia; Sepúlveda Fernández, Marcos Ernesto
- ItemDiseño curricular en Anestesiología utilizando la simulación como herramienta docente (réplica)(2014) Corvetto Aqueveque, Marcia Antonia; Altermatt, Fernando; Delfino, Alejandro
- ItemEffect of acute arterial hypertension on morphine requirements and postsurgical pain(2015) Delfino, Alejandro; De La Fuente, Natalia; Altermatt, Fernando; Cortínez Fernández, Luis Ignacio; Echevarría, Ghislaine C.; Delfino, Alejandro; De La Fuente, Natalia; Altermatt, Fernando; Cortínez Fernández, Luis Ignacio; Echevarria, Ghislaine C.
- Item¿Es efectiva la ketamina endovenosa para el manejo del dolor postoperatorio en adultos?(2017) Stuardo,Camila; Lobos Urbina, Diego; Altermatt, Fernando
- Item¿Es efectiva la lidocaína endovenosa para disminuir el dolor y acelerar la recuperación postoperatoria?(2017) González, María Magdalena; Altermatt, Fernando
- Item¿Es efectiva la pregabalina perioperatoria para reducir el dolor postoperatorio en cirugías mayores?(2017) Canihuante, José; Molina, Ian; Altermatt, Fernando
- Item¿Es efectivo y seguro el betabloqueo perioperatorio en pacientes sometidos a cirugía no cardíaca?(2016) Armstrong, Andrés; Rada G., Gabriel; Altermatt, Fernando
- ItemInclination towards research and the pursuit of a research career among medical students: an international cohort study(2018) Ha, Tam C.; Altermatt, Fernando; Ng, Sheryl.; Chen, Cynthia.; Yong, Sook K.; Koh, Gerald C H.; Tan, Say B.; Malhotra, Rahul.; Seim, Arnfinn.; Biderman, Aya.Abstract Background Involvement of clinicians in biomedical research is imperative for the future of healthcare. Several factors influence clinicians’ inclination towards research: the medical school experience, exposure to research article reading and writing, and knowledge of research. This cohort study follows up medical students at time of graduation to explore changes in their inclination towards research and pursuing a research career compared to their inclination at time of entry into medical school. Methods Students from medical schools in six different countries were enrolled in their first year of school and followed-up upon graduation in their final year. Students answered the same self-administered questionnaire at both time points. Changes in inclination towards research and pursuing a research career were assessed. Factors correlated with these changes were analysed. Results Of the 777 medical students who responded to the study questionnaire at entry into medical school, 332 (42.7%) completed the follow-up survey. Among these 332 students, there was no significant increase in inclination towards research or pursuing a research career over the course of their medical schooling. Students from a United States based school, in contrast to those from schools other countries, were more likely to report having research role models to guide them (51.5% vs. 0%–26.4%) and to have published in a peer-reviewed journal (75.7% vs. 8.9%–45%). Absence of a role model was significantly associated with a decrease in inclination towards research, while an increased desire to learn more about statistics was significantly associated with an increase in inclination towards pursuing a research career. Conclusion Most medical students did not experience changes in their inclination towards research or pursuing a research career over the course of their medical schooling. Factors that increased their inclination to undertaking research or pursuing a research career were availability of a good role model, and a good knowledge of both the research process and the analytical tools required.Abstract Background Involvement of clinicians in biomedical research is imperative for the future of healthcare. Several factors influence clinicians’ inclination towards research: the medical school experience, exposure to research article reading and writing, and knowledge of research. This cohort study follows up medical students at time of graduation to explore changes in their inclination towards research and pursuing a research career compared to their inclination at time of entry into medical school. Methods Students from medical schools in six different countries were enrolled in their first year of school and followed-up upon graduation in their final year. Students answered the same self-administered questionnaire at both time points. Changes in inclination towards research and pursuing a research career were assessed. Factors correlated with these changes were analysed. Results Of the 777 medical students who responded to the study questionnaire at entry into medical school, 332 (42.7%) completed the follow-up survey. Among these 332 students, there was no significant increase in inclination towards research or pursuing a research career over the course of their medical schooling. Students from a United States based school, in contrast to those from schools other countries, were more likely to report having research role models to guide them (51.5% vs. 0%–26.4%) and to have published in a peer-reviewed journal (75.7% vs. 8.9%–45%). Absence of a role model was significantly associated with a decrease in inclination towards research, while an increased desire to learn more about statistics was significantly associated with an increase in inclination towards pursuing a research career. Conclusion Most medical students did not experience changes in their inclination towards research or pursuing a research career over the course of their medical schooling. Factors that increased their inclination to undertaking research or pursuing a research career were availability of a good role model, and a good knowledge of both the research process and the analytical tools required.Abstract Background Involvement of clinicians in biomedical research is imperative for the future of healthcare. Several factors influence clinicians’ inclination towards research: the medical school experience, exposure to research article reading and writing, and knowledge of research. This cohort study follows up medical students at time of graduation to explore changes in their inclination towards research and pursuing a research career compared to their inclination at time of entry into medical school. Methods Students from medical schools in six different countries were enrolled in their first year of school and followed-up upon graduation in their final year. Students answered the same self-administered questionnaire at both time points. Changes in inclination towards research and pursuing a research career were assessed. Factors correlated with these changes were analysed. Results Of the 777 medical students who responded to the study questionnaire at entry into medical school, 332 (42.7%) completed the follow-up survey. Among these 332 students, there was no significant increase in inclination towards research or pursuing a research career over the course of their medical schooling. Students from a United States based school, in contrast to those from schools other countries, were more likely to report having research role models to guide them (51.5% vs. 0%–26.4%) and to have published in a peer-reviewed journal (75.7% vs. 8.9%–45%). Absence of a role model was significantly associated with a decrease in inclination towards research, while an increased desire to learn more about statistics was significantly associated with an increase in inclination towards pursuing a research career. Conclusion Most medical students did not experience changes in their inclination towards research or pursuing a research career over the course of their medical schooling. Factors that increased their inclination to undertaking research or pursuing a research career were availability of a good role model, and a good knowledge of both the research process and the analytical tools required.Abstract Background Involvement of clinicians in biomedical research is imperative for the future of healthcare. Several factors influence clinicians’ inclination towards research: the medical school experience, exposure to research article reading and writing, and knowledge of research. This cohort study follows up medical students at time of graduation to explore changes in their inclination towards research and pursuing a research career compared to their inclination at time of entry into medical school. Methods Students from medical schools in six different countries were enrolled in their first year of school and followed-up upon graduation in their final year. Students answered the same self-administered questionnaire at both time points. Changes in inclination towards research and pursuing a research career were assessed. Factors correlated with these changes were analysed. Results Of the 777 medical students who responded to the study questionnaire at entry into medical school, 332 (42.7%) completed the follow-up survey. Among these 332 students, there was no significant increase in inclination towards research or pursuing a research career over the course of their medical schooling. Students from a United States based school, in contrast to those from schools other countries, were more likely to report having research role models to guide them (51.5% vs. 0%–26.4%) and to have published in a peer-reviewed journal (75.7% vs. 8.9%–45%). Absence of a role model was significantly associated with a decrease in inclination towards research, while an increased desire to learn more about statistics was significantly associated with an increase in inclination towards pursuing a research career. Conclusion Most medical students did not experience changes in their inclination towards research or pursuing a research career over the course of their medical schooling. Factors that increased their inclination to undertaking research or pursuing a research career were availability of a good role model, and a good knowledge of both the research process and the analytical tools required.
- ItemInternational fragility fracture network delphi consensus statement on the principles of anaesthesia for patients with hip fracture(2018) White, S.M.; Altermatt, Fernando; Barry, J.; Ben‐David, B.; Coburn, M.; Coluzzi, F.; Degoli, M.; Dillane, D.; Foss, N.B.; Gelmanas, A.
- ItemIntra-operative lidocaine in the prevention of vomiting after elective tonsillectomy in children(2018) Echevarría, Ghislaine C.; Altermatt, Fernando; Paredes, S.; Puga, V.; Auad, H.; Veloso, A.; Elgueta Le-Beuffe, María Francisca
- ItemLevobupivacaine absorption pharmacokinetics with and without epinephrine during TAP block : analysis of doses based on the associated risk of local anaesthetic toxicity(2016) Miranda Hiriart, Pablo; Corvetto Aqueveque, Marcia Antonia; Altermatt, Fernando; Araneda Levy, Ana María; Echevarria, G.; Cortínez Fernández, Luis Ignacio
- ItemMaintenance of chronicity signatures in fibroblasts isolated from recessive dystrophic epidermolysis bullosa chronic wound dressings under culture conditions(2023) De Gregorio, Cristian; Catalán, Evelyng; Garrido, Gabriel; Morandé, Pilar; Bennett, Jimena C.; Muñoz, Catalina; Cofré, Glenda; Huang, Ya-Lin; Cuadra, Bárbara; Murgas, Paola; Calvo Bascuñan, Margarita; Altermatt, Fernando; Yubero, María J.; Palisson, Francis; South, Andrew P.; Ezquer, Marcelo; Fuentes, IgnaciaBackground Recessive Dystrophic Epidermolysis Bullosa (RDEB) is a rare inherited skin disease caused by variants in the COL7A1 gene, coding for type VII collagen (C7), an important component of anchoring fibrils in the basement membrane of the epidermis. RDEB patients suffer from skin fragility starting with blister formation and evolving into chronic wounds, inflammation and skin fibrosis, with a high risk of developing aggressive skin carcinomas. Restricted therapeutic options are limited by the lack of in vitro models of defective wound healing in RDEB patients. Results In order to explore a more efficient, non-invasive in vitro model for RDEB studies, we obtained patient fibroblasts derived from discarded dressings) and examined their phenotypic features compared with fibroblasts derived from non-injured skin of RDEB and healthy-donor skin biopsies. Our results demonstrate that fibroblasts derived from RDEB chronic wounds (RDEB-CW) displayed characteristics of senescent cells, increased myofibroblast differentiation, and augmented levels of TGF-β1 signaling components compared to fibroblasts derived from RDEB acute wounds and unaffected RDEB skin as well as skin from healthy-donors. Furthermore, RDEB-CW fibroblasts exhibited an increased pattern of inflammatory cytokine secretion (IL-1β and IL-6) when compared with RDEB and control fibroblasts. Interestingly, these aberrant patterns were found specifically in RDEB-CW fibroblasts independent of the culturing method, since fibroblasts obtained from dressing of acute wounds displayed a phenotype more similar to fibroblasts obtained from RDEB normal skin biopsies. Conclusions Our results show that in vitro cultured RDEB-CW fibroblasts maintain distinctive cellular and molecular characteristics resembling the inflammatory and fibrotic microenvironment observed in RDEB patients’ chronic wounds. This work describes a novel, non-invasive and painless strategy to obtain human fibroblasts chronically subjected to an inflammatory and fibrotic environment, supporting their use as an accessible model for in vitro studies of RDEB wound healing pathogenesis. As such, this approach is well suited to testing new therapeutic strategies under controlled laboratory conditions.
- ItemPerioperative lumbar plexus block and cardiac ischemia in patients with hip fracture : randomized clinical trial(2018) Altermatt, Fernando; Echevarría, Ghislaine C.; Cuadra F., Juan Carlos de la; Baeza Vergara, Ricardo Gabriel; Ferrada, Marcela; De La Cuadra Fontaine, Juan Carlos; Corvetto Aqueveque, Marcia Antonia
- ItemPharmacokinetics of levobupivacaine with epinephrine in transversus abdominis plane block for postoperative analgesia after caesarean section(2018) Lacassie Quiroga, Héctor; Rolle, A.; Cortínez Fernández, Luis Ignacio; Solari Gajardo, Sandra; Corvetto Aqueveque, Marcia Antonia; Altermatt, Fernando