Browsing by Author "Alarcon, G. S."
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- ItemIs familial lupus different from sporadic lupus? Data from LUMINA (LXXIII), a multiethnic US cohort(SAGE PUBLICATIONS LTD, 2010) Burgos, P. I.; McGwin, G., Jr.; Reveille, J. D.; Vila, L. M.; Brown, E. E.; Alarcon, G. S.The aim of this study was to characterize the clinical features of familial lupus, and determine its influence on damage accrual and survival using data from LUMINA, a longitudinal multiethnic US cohort. Familial lupus was defined as patients with a first-degree relative with systemic lupus erythematosus. Relative risks were estimated by logistic regression; odds ratios (ORs) and their 95% confidence intervals (CIs) were the measure of association for familial lupus. Hazard ratios were calculated using Cox proportional hazards adjusted for potential confounders for damage and survival. Of 644 patients, 32 had familial and 612 had sporadic lupus; both groups were of comparable age (similar to 36 years). Patients with familial lupus were, in decreasing order of frequency, siblings, parents and children. In multivariable analyses, mucosal ulcers (OR = 1.92, 95% CI 0.65-5.70), mitral valve prolapse (OR = 1.74, 95% CI 0.50-6.10), cerebrovascular disease (OR = 4.18, 95% CI 0.98-17.76) and oral contraceptive use (ever/never; OR = 2.51, 95% CI 0.88-7.19) were more likely in familial lupus, but a history of low platelet count (<150,000/mm(3); OR = 0.31, 95% CI 0.08-1.17) and pulmonary disease activity (OR = 0.39, 95% CI 0.14-1.20) were less likely. However, none of these associations reached statistical significance. Familial lupus was not significantly associated with a shorter time to either damage accrual or death (HR = 0.77, 95% CI 0.37-1.59, p = 0.4746 and HR = 0.20, 95% CI 0.03-1.47, p = 0.2020, respectively). We conclude that although some clinical differences were observed between patients with familial and sporadic lupus, familial lupus was not associated with a significantly greater disease burden (damage, survival) than sporadic lupus. Lupus (2010) 19, 1331-1336.
- ItemThe impact of rural residency on the expression and outcome of systemic lupus erythematosus: data from a multiethnic Latin American cohort(SAGE PUBLICATIONS LTD, 2012) Pons Estel, G. J.; Saurit, V.; Alarcon, G. S.; Hachuel, L.; Boggio, G.; Wojdyla, D.; Alfaro Lozano, J. L.; Garcia de la Torre, I.; Massardo, L.; Esteva Spinetti, M. H.; Guibert Toledano, M.; Ramirez Gomez, L. A.; Lavras Costallat, L. T.; Sauza del Pozo, M. J.; Silveira, L. H.; Cavalcanti, F.; Pons Estel, B. A.Objective: The objective of this paper is to examine the role of place of residency in the expression and outcomes of systemic lupus erythematosus (SLE) in a multi-ethnic Latin American cohort. Patients and methods: SLE patients (
- ItemUse of rituximab for the treatment of rheumatoid arthritis: the Latin American context(OXFORD UNIV PRESS, 2008) Soriano, E. R.; Galarza Maldonado, C.; Cardiel, M. H.; Pons Estel, B. A.; Massardo, L.; Caballero Uribe, C. V.; Achurra Castillo, A. F.; Barile Fabris, L. A.; Chavez Corrales, J.; Diaz Coto, J. F.; Esteva Spinetti, M. H.; Guibert Toledano, M.; Palazuelos, F. Irazoque; Keiserman, M. W.; Lomonte, A. V.; Mota, L. M. H.; Villasenor, C. Pineda; Alarcon, G. S.; GLADAR Grp Latino Americano Estud