Browsing by Author "Aguirre Polanco, Carolina"
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- ItemAsociación entre el estado nutricional y la prevalencia de pie plano en niños chilenos de 6 a 10 años de edad(2016) López Fuenzalida, Antonio Eduardo; Rodríguez Canales, Carolina; Reyes Ponce, Alvaro; Contreras Molina, Ángela; Fernández Quezada, Javiera; Aguirre Polanco, Carolina
- ItemDocohexaenoic acid improves the reduced umbilical vein relaxation observed in the offspring of pregnancies with maternal obesity(2017) Farías Jofré, Marcelo Enrique; Villalobos Labra, Roberto Esteban; Solari Gajardo, Sandra; Aguirre Polanco, Carolina; Samith Catalán, Bárbara Patricia; Rojas Vidal, María JoséBackground and objectives: Maternal obesity (MO) is associated with increased risk of long term metabolic risk in the offspring (REF), probably involving mechanisms such as early programming of insulin resistance in fetal and neonatal tissues. On the other hand, exposure to the polyunsaturated acid Docohexaenoic acid (DHA) has been related with increased insulin response in multiple cell types. The aims of our study were to evaluate the in vitro effect of DHA on vascular response of umbilical vein to insulin, and the role of the intracellular inhibitory phosphorylation of the insulin receptor substrate-1. Methods: Umbilical cords from normal and MO pregnant woman attending to obstetrics service at the Clinical Hospital of Pontificia Universidad Catolica de Chile were obtained after informed consent. Isolated rings of umbilical vein were used to evaluate vasodilatation capacity by wire-myography, in absence or presence of insulin (10-10 to 10-6 uM, 0-20 min) and DHA (100 uM, 12 h). Primary cultures of human umbilical vein endothelial cells (HUVEC) were used to evaluated phosphorylated and total protein levels of IRS-1 in cells exposed or not to insulin (1 nM, 30 min), in absence or presence of DHA (100 uM, 12 h). 308 Ann Nutr Metab 2017;71(suppl 2):1–1433 Oral Abstracts Results: Insulin produces a significant vasodilation (20%) in umbilical vein rings from normal pregnancies, an effect that was absent in MO-derived umbilical rings. This vasodilator effect of insulin was recovered in umbilical vein rings from MO pregnancies pre-incubated with DHA. In addition, HUVEC from MO pregnancies showed increased levels of IRS-1 phosphorylated in serine307, compared with normal cells, a difference that was reduced by DHA, even in presence of insulin. Conclusions: In vitro addition of DHA recovers the reduced vascular response to insulin in umbilical vein from MO pregnancies, involving a reduction of the inhibitory phosphorylation of IRS in serine307.
- ItemEsteatohepatitis no-alcohólica: Desarrollo silencioso de una emergencia en salud pública(Soc. Chilena Nutrición, Bromatología & Toxicología, 2023) Pettinelli, Paulina; Fernandez-Verdejo, Rodrigo; Aguirre Polanco, Carolina
- ItemOral Administration of the Endocannabinoid Anandamide during Lactation: Effects on Hypothalamic Cannabinoid Type 1 Receptor and Food Intake in Adult Mice.(2017) Aguirre Polanco, Carolina; Castillo, V.; Llanos, Miguel
- ItemReduced docosahexaenoic acid content in neonatal erythrocytes from obese mothers(2017) Samith Catalán, Bárbara Patricia; Farías Jofré, Marcelo Enrique; Villalobos Labra, Roberto Esteban; Solari Gajardo, Sandra; Aguirre Polanco, Carolina; Rojas Reyes, María José
- ItemResting energy metabolism and sweet taste preference during the menstrual cycle in healthy women(2023) Malo-Vintimilla, Lorena; Aguirre Polanco, Carolina; Vergara, Angie; Fernández-Verdejo, Rodrigo; Galgani, Jose E.Differences in blood concentration of sex hormones in the follicular (FP) and luteal (LP) phases may influence energy metabolism in women. We compared fasting energy metabolism and sweet taste preference on a representative day of the FP and LP in twenty healthy women (25·3 (SD 5·1) years, BMI: 22·2 (SD 2·2) kg/m2) with regular self-reported menses and without the use of hormonal contraceptives. From the self-reported duration of the three prior menstrual cycles, the predicted FP and LP visits were scheduled for days 5–12 and 20–25 after menses, respectively. The order of the FP and LP visits was randomly assigned. On each visit, RMR and RQ by indirect calorimetry, sweet taste preference by the Monell two-series forced-choice tracking procedure, serum fibroblast growth factor 21 by a commercial ELISA (FGF21, a liver-derived protein with action in energy balance, fuel oxidation and sugar preference) and dietary food intake by a 24-h dietary recall were determined. Serum progesterone and oestradiol concentrations displayed the expected differences between phases. RMR was lower in the FP v. LP (5042 (SD 460) v. 5197 (SD 490) kJ/d, respectively; P = 0·04; Cohen effect size, drm = 0·33), while RQ showed borderline significant higher values (0·84 (SD 0·05) v. 0·81 (SD 0·05), respectively; P = 0·07; drm = 0·62). Also, in the FP v. LP, sweet taste preference was lower (12 (SD 8) v. 16 (SD 9) %; P = 0·04; drm = 0·47) concomitant with higher serum FGF21 concentration (294 (SD 164) v. 197 (SD 104) pg/ml; P < 0·01; drm = 0·66). The menstrual cycle is associated with changes in energy expenditure, sweet taste preference and oxidative fuel partitioning.
- ItemSobrepeso y obesidad en enfermedad celiaca : expresión del perfil de interleuquinas Th17(2018) Parada Daza, Alejandra; Aguirre Polanco, Carolina; Pérez Bravo, Francisco
- ItemStress during Lactation Induces Insulin Resistance Associated with an Increase in Type 1 Cannabinoid Receptors in Liver and Adipose Tissue(2019) Fonseca, L.; Castillo, V.; Aguirre Polanco, Carolina; Silva, P.; Ronco, A. M.; Llanos, M.
- ItemThe endocannabinoid anandamide during lactation increases body fat content and CB1 receptor levels in mice adipose tissue(2015) Aguirre Polanco, Carolina; Castillo V., A.; Llanos, M. N.
- ItemVolver a lo básico: líneas estratégicas 2018(2017) Baladia, Eduard; Martínez-Rodríguez, Rodrigo; Navarrete-Muñoz, Eva María; Romá-Ferri, María Teresa; Olmedo-Requena, Rocío; Benítez Brito, Néstor; Soler, Carla; García de la Hera, Manuela; Dávila-Batista, Verónica; Aguirre Polanco, Carolina; Souza-Teixeira, Fernenada; Soares, Panmela