Polymorphisms in maternal and fetal genes encoding for proteins involved in extracellular matrix metabolism alter the risk for small-for-gestational-age
link https://doi.org/10.3109/14767058.2010.497572account_box Edwards, Digna R. Velezaccount_box Romero, Robertoaccount_box Kusanovic, Juan Pedroaccount_box Hassan, Sonia S.account_box Mazaki Tovi, Shaliaccount_box Vaisbuch, Ediaccount_box Kim, Chong Jaiaccount_box Erez, Offeraccount_box Chaiworapongsa, Tinnakornaccount_box Pearce, Brad D.account_box Bartlett, Jacquelaineaccount_box Friel, Lara A.account_box Salisbury, Benjamin A.account_box Anant, Madan Kumaraccount_box Vovis, Gerald F.account_box Lee, Min Seobaccount_box Gomez, Ricardoaccount_box Behnke, Ernestoaccount_box Oyarzun, Enriqueaccount_box Tromp, Gerardaccount_box Menon, Ramkumaraccount_box Williams, Scott M.
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Objective. To examine the association between maternal and fetal genetic variants and small-for-gestational-age (SGA).
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| Autor | Edwards, Digna R. Velez Romero, Roberto Kusanovic, Juan Pedro Hassan, Sonia S. Mazaki Tovi, Shali Vaisbuch, Edi Kim, Chong Jai Erez, Offer Chaiworapongsa, Tinnakorn Pearce, Brad D. Bartlett, Jacquelaine Friel, Lara A. Salisbury, Benjamin A. Anant, Madan Kumar Vovis, Gerald F. Lee, Min Seob Gomez, Ricardo Behnke, Ernesto Oyarzun, Enrique Tromp, Gerard Menon, Ramkumar Williams, Scott M. |
| Título | Polymorphisms in maternal and fetal genes encoding for proteins involved in extracellular matrix metabolism alter the risk for small-for-gestational-age |
| Revista | JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE |
| ISSN | 1476-7058 |
| ISSN electrónico | 1476-4954 |
| Volumen | 24 |
| Número de publicación | 2 |
| Página inicio | 362 |
| Página final | 380 |
| Fecha de publicación | 2011 |
| Resumen | Objective. To examine the association between maternal and fetal genetic variants and small-for-gestational-age (SGA). Methods. A case-control study was conducted in patients with SGA neonates (530 maternal and 436 fetal) and controls (599 maternal and 628 fetal); 190 candidate genes and 775 SNPs were studied. Single-locus, multi-locus and haplotype association analyses were performed on maternal and fetal data with logistic regression, multifactor dimensionality reduction (MDR) analysis, and haplotype-based association with 2 and 3 marker sliding windows, respectively. Ingenuity pathway analysis (IPA) software was used to assess pathways that associate with SGA. Results. The most significant single-locus association in maternal data was with a SNP in tissue inhibitor of metalloproteinase 2 (TIMP2) (rs2277698 OR = 1.71, 95% CI [1.26-2.32], p = 0.0006) while in the fetus it was with a SNP in fibronectin 1 isoform 3 preproprotein (FN1) (rs3796123, OR = 1.46, 95% CI [1.20-1.78], p = 0.0001). Both SNPs were adjusted for potential confounders (maternal body mass index and fetal sex). Haplotypc analyses resulted in associations in alpha 1 type I collagen preproprotein (COL1A1, rs1007086-rs2141279-rs17639446, global p = 0.006) in mothers and FN1 (rs2304573-rs1250204-rs1250215, global p = 0.045) in fetuses. Multi-locus analyses with MDR identified a two SNP model with maternal variants collagen type V alpha 2 (COL5A2) and plasminogen activator urokinase (PLAU) predicting SGA outcome correctly 59% of the time (p = 0.035). Conclusions. Genetic variants in extracellular matrix-related genes showed significant single-locus association with SGA. These data are consistent with other studies that have observed elevated circulating fibronectin concentrations in association with increased risk of SGA. The present study supports the hypothesis that DNA variants can partially explain the risk of SGA in a cohort of Hispanic women. |
| Derechos | registro bibliográfico |
| Agencia financiadora | Perinatology Research Branch, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, DHHS EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT |
| DOI | 10.3109/14767058.2010.497572 |
| Editorial | TAYLOR & FRANCIS LTD |
| Enlace | |
| Id de publicación en Pubmed | MEDLINE:20617897 |
| Id de publicación en WoS | WOS:000287008100031 |
| Paginación | 19 páginas |
| Palabra clave | DNA variants extracellular matrix genetic association study genomics genotype haplotype high dimensional biology SNP intrauterine growth restriction genetic epidemiology complex disease INTRAUTERINE GROWTH RESTRICTION UTERINE ARTERY DOPPLER LOW-BIRTH-WEIGHT MULTIFACTOR-DIMENSIONALITY REDUCTION HARDY-WEINBERG EQUILIBRIUM FALSE DISCOVERY RATE SIB-PAIR LINKAGE PLACENTAL GROWTH FACTOR RECEPTOR-1 ANGIOGENIC FACTORS |
| Tema ODS | 03 Good Health and Well-being 05 Gender Equality |
| Tema ODS español | 03 Salud y bienestar 05 Igualdad de género |
| Tipo de documento | artículo |