Plasma protein Z concentrations in pregnant women with idiopathic intrauterine bleeding and in women with spontaneous preterm labor
link https://doi.org/10.1080/14767050701398272account_box Kusanovic, Juan Pedroaccount_box Espinoza, Jimmyaccount_box Romero, Robertoaccount_box Hoppensteadt, Debraaccount_box Nien, Jyh Kaeaccount_box Kim, Chong Jaiaccount_box Erez, Offeraccount_box Soto, Eleazaraccount_box Fareed, Jawedaccount_box Edwin, Samaccount_box Chaiworapongsa, Tinnakornaccount_box Than, Nador G.account_box Yoon, Bo Hyunaccount_box Gomez, Ricardoaccount_box Papp, Zoltanaccount_box Hassan, Sonia S.
Comparte este registro
Objectives. Preterm parturition has been associated with decidual vascular disorders and excessive thrombin generation. The objective of this study was to examine maternal plasma concentrations of protein Z in normal pregnancies, as well as in those presenting with spontaneous preterm labor (PTL) and intrauterine bleeding during pregnancy.
Registro Sencillo
Registro Completo
| Autor | Kusanovic, Juan Pedro Espinoza, Jimmy Romero, Roberto Hoppensteadt, Debra Nien, Jyh Kae Kim, Chong Jai Erez, Offer Soto, Eleazar Fareed, Jawed Edwin, Sam Chaiworapongsa, Tinnakorn Than, Nador G. Yoon, Bo Hyun Gomez, Ricardo Papp, Zoltan Hassan, Sonia S. |
| Título | Plasma protein Z concentrations in pregnant women with idiopathic intrauterine bleeding and in women with spontaneous preterm labor |
| Revista | JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE |
| ISSN | 1476-7058 |
| ISSN electrónico | 1476-4954 |
| Volumen | 20 |
| Número de publicación | 6 |
| Página inicio | 453 |
| Página final | 463 |
| Fecha de publicación | 2007 |
| Resumen | Objectives. Preterm parturition has been associated with decidual vascular disorders and excessive thrombin generation. The objective of this study was to examine maternal plasma concentrations of protein Z in normal pregnancies, as well as in those presenting with spontaneous preterm labor (PTL) and intrauterine bleeding during pregnancy. Study design. A cross-sectional study was designed to include patients with preterm labor and intact membranes and those with idiopathic intrauterine bleeding during pregnancy. Protein Z plasma concentrations were measured in the following groups: (1) normal pregnant women (n = 71); (2) patients at term with (n = 67) and without labor (n = 88); (3) patients with spontaneous PTL before 34 weeks who were classified into: (a) PTL with intra-amniotic infection/inflammation (IAI; n = 35), (b) PTL without IAI (n = 54), and (c) patients with PTL who delivered at term (n = 49); and (4) patients with idiopathic intrauterine bleeding in the second and third trimester who were divided into: (a) subsequent spontaneous PTL and delivery, and (b) term delivery. Maternal plasma protein Z concentration was measured by a specific and sensitive immunoassay. Moreover, the amniotic fluid concentration of protein Z was determined in a subset of patients with preterm labor (n = 30). Results. (1) There was no correlation between maternal plasma protein Z concentration and gestational age in normal pregnant women. (2) The mean maternal plasma concentration of protein Z was significantly lower in women during spontaneous labor at term than in those not in labor (mean 2.15 mg/mL (95% CI 2.01-2.29) vs. mean 2.45 +/- 0.52 mg/mL (95% CI 2.34 -2.56), respectively; p = 0.001). (3) Women with PTL without IAI who delivered preterm had a significantly lower mean protein Z concentration than normal pregnant women (mean 2.12 mg/mL (95% CI 1.98-2.26) vs. mean 2.39 mg/mL (95% CI 2.28-2.5); p = 0.008). (4) Of interest, PTL with IAI was not associated with lower plasma concentrations of protein Z, nor were those with PTL who delivered at term (p > 0.05 for each). (5) No differences were found in the maternal plasma concentrations of anti-protein Z antibodies between normal pregnancies and those with spontaneous PTL. (6) Patients with idiopathic intrauterine bleeding who had spontaneous PTL and delivery had a significantly lower mean plasma protein Z concentration than those who delivered at term (mean 1.24 mg/mL (95% CI 1.08-1.4) vs. mean 1.49 +/- 0.47 mg/mL (95% CI 1.33-1.65), respectively; p = 0.03). (7) Amniotic fluid was found to contain immunoreactive protein Z. Conclusions. (1) Patients with PTL leading to preterm delivery in the absence of IAI had a significantly lower plasma concentration of protein Z than those with normal pregnancies. (2) Patients with idiopathic intrauterine bleeding and subsequently spontaneous PTL and delivery had a significantly lower plasma concentration of protein Z than those with idiopathic intrauterine bleeding who delivered at term. (3) Protein Z was present in the amniotic fluid of patients with PTL. Collectively, these observations suggest that a subgroup of patients with PTL have a hemostatic disorder that involves bleeding/thrombosis as a mechanism of disease. |
| Derechos | acceso restringido |
| Agencia financiadora | EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT Intramural NIH HHS |
| DOI | 10.1080/14767050701398272 |
| Editorial | TAYLOR & FRANCIS LTD |
| Enlace | |
| Id de publicación en Pubmed | MEDLINE:17674255 |
| Id de publicación en WoS | WOS:000247611800004 |
| Paginación | 11 páginas |
| Palabra clave | coagulation pregnancy protein Z amniotic fluid parturition thrombin anti-protein Z antibodies vaginal bleeding FACTOR-V-LEIDEN Z DEFICIENCY ISCHEMIC STROKE AMNIOTIC-FLUID PROTHROMBOTIC PHENOTYPE INTRAAMNIOTIC INFECTION PREMATURE LABOR Z ANTIBODIES PARTURITION INHIBITOR |
| Tema ODS | 05 Gender Equality 03 Good Health and Well-being |
| Tema ODS español | 05 Igualdad de género 03 Salud y bienestar |
| Tipo de documento | artículo |