An elevated fetal interleukin-6 concentration can be observed in fetuses with anemia due to Rh alloimmunization: implications for the understanding of the fetal inflammatory response syndrome
link https://doi.org/10.3109/14767058.2010.507294account_box Vaisbuch, Ediaccount_box Romero, Robertoaccount_box Gomez, Ricardoaccount_box Kusanovic, Juan Pedroaccount_box Mazaki Tovi, Shaliaccount_box Chaiworapongsa, Tinnakornaccount_box Hassan, Sonia S.
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Methods. aEuro integral Fetal blood sampling was performed in sensitized Rh-D negative women with suspected fetal anemia (n aEuroS== aEuroS16). Fetal anemia was diagnosed according to reference range nomograms established for the assessment of fetal hematologic parameters. An elevated fetal plasma IL-6 concentration was defined using a cutoff of > 11 pg/ml. Concentrations of IL-6 were determined by immunoassay. Non-parametric statistics were used for analysis.
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| Autor | Vaisbuch, Edi Romero, Roberto Gomez, Ricardo Kusanovic, Juan Pedro Mazaki Tovi, Shali Chaiworapongsa, Tinnakorn Hassan, Sonia S. |
| Título | An elevated fetal interleukin-6 concentration can be observed in fetuses with anemia due to Rh alloimmunization: implications for the understanding of the fetal inflammatory response syndrome |
| Revista | JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE |
| ISSN | 1476-7058 |
| ISSN electrónico | 1476-4954 |
| Volumen | 24 |
| Número de publicación | 3 |
| Página inicio | 391 |
| Página final | 396 |
| Fecha de publicación | 2011 |
| Resumen | Methods. aEuro integral Fetal blood sampling was performed in sensitized Rh-D negative women with suspected fetal anemia (n aEuroS== aEuroS16). Fetal anemia was diagnosed according to reference range nomograms established for the assessment of fetal hematologic parameters. An elevated fetal plasma IL-6 concentration was defined using a cutoff of > 11 pg/ml. Concentrations of IL-6 were determined by immunoassay. Non-parametric statistics were used for analysis. Results. aEuro integral(1) The prevalence of an elevated fetal plasma IL-6 was 25%% (4/16); (2) there was an inverse relationship between the fetal hematocrit and IL-6 concentration -- the lower the hematocrit, the higher the fetal IL-6 (r aEuroS== aEuroS--0.68, p aEuroS== aEuroS0.004); (3) fetuses with anemia had a significantly higher plasma IL-6 concentration than those without anemia (3.74 pg/ml, interquartile range (IQR) 1.18--2.63 vs. 1.46 pg/ml, IQR 1.76--14.7; p aEuroS== aEuroS0.02); (4) interestingly, all fetuses with an elevated plasma IL-6 concentration had anemia (prevalence 40%%, 4/10), while in the group without anemia, none had an elevated fetal plasma IL-6. Conclusions. aEuro integral An elevation in fetal plasma IL-6 can be observed in a subset of fetuses with anemia due to Rh alloimmunization. This observation suggests that the hallmark of FIRS can be caused by non-infection-related insults. Further studies are required to determine whether the prognosis of FIRS caused by intra-amniotic infection/inflammation is different from that induced by alloimmunization. |
| Derechos | acceso restringido |
| Agencia financiadora | Perinatology Research Branch Division of Intramural Research Eunice Kennedy Shriver National Institute of Child Health Human Development, NIH, DHHS EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT |
| DOI | 10.3109/14767058.2010.507294 |
| Editorial | TAYLOR & FRANCIS LTD |
| Enlace | |
| Id de publicación en Pubmed | MEDLINE:20701435 |
| Id de publicación en WoS | WOS:000286993000001 |
| Paginación | 6 páginas |
| Palabra clave | Fetal anemia FIRS interleukin-6 pregnancy Rh hemolytic disease PRETERM PREMATURE RUPTURE UMBILICAL-CORD PLASMA INTRAAMNIOTIC INFLAMMATION RHESUS ALLOIMMUNIZATION THYMIC INVOLUTION CEREBRAL-PALSY CHORIOAMNIONITIS MANAGEMENT ASSOCIATION ACTIVATION |
| Tema ODS | 03 Good Health and Well-being 05 Gender Equality |
| Tema ODS español | 03 Salud y bienestar 05 Igualdad de género |
| Tipo de documento | artículo |