Optimal length of triple therapy for H pylori eradication in a population with high prevalence of infection in Chile
link https://doi.org/10.3748/wjg.v13.i21.2967account_box Riquelme, Arnoldoaccount_box Soza, Alejandroaccount_box Pedreros, Cesaraccount_box Bustamante, Andreaaccount_box Valenzuela, Felipeaccount_box Otarola, Franciscoaccount_box Abbott, Eduardoaccount_box Arellano, Marcoaccount_box Medina, Brendaaccount_box Pattillo, Alejandroaccount_box Greig, Douglasaccount_box Arrese, Marcoaccount_box Rollan, Antonio
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AIM: To compare the efficacy of 7-d versus 14-d triple therapy for the treatment of H pylori infection in Chile, with a prevalence of 73% in general population. METHODS: H pylori-infected patients diagnosed by rapid urease test, with non-ulcer dyspepsia or peptic ulcer disease were randomized to receive omeprazole 20 mg bid, amoxicillin 1 g bid, and clarithromycin 500 mg bid for 7 (OAC7) or 14 (OAC14) d. Primary outcome was eradication rate 6 wk after the treatment. Subgroup analysis was carried out considering the eradication rate among patients with or without peptic ulcer disease and eradication rate among smokers or non-smokers.
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| Autor | Riquelme, Arnoldo Soza, Alejandro Pedreros, Cesar Bustamante, Andrea Valenzuela, Felipe Otarola, Francisco Abbott, Eduardo Arellano, Marco Medina, Brenda Pattillo, Alejandro Greig, Douglas Arrese, Marco Rollan, Antonio |
| Título | Optimal length of triple therapy for H pylori eradication in a population with high prevalence of infection in Chile |
| Revista | WORLD JOURNAL OF GASTROENTEROLOGY |
| ISSN | 1007-9327 |
| ISSN electrónico | 2219-2840 |
| Volumen | 13 |
| Número de publicación | 21 |
| Página inicio | 2967 |
| Página final | 2972 |
| Fecha de publicación | 2007 |
| Resumen | AIM: To compare the efficacy of 7-d versus 14-d triple therapy for the treatment of H pylori infection in Chile, with a prevalence of 73% in general population. METHODS: H pylori-infected patients diagnosed by rapid urease test, with non-ulcer dyspepsia or peptic ulcer disease were randomized to receive omeprazole 20 mg bid, amoxicillin 1 g bid, and clarithromycin 500 mg bid for 7 (OAC7) or 14 (OAC14) d. Primary outcome was eradication rate 6 wk after the treatment. Subgroup analysis was carried out considering the eradication rate among patients with or without peptic ulcer disease and eradication rate among smokers or non-smokers. RESULTS: One hundred and thirty-one patients were randomized to OAC7 (n = 69) or OAC14 (n = 62). The overall eradication rate (intention-to-treat) was 78.3% in OAC7 and 85.5% in OAC14 groups, without a significant difference (P = 0.37). No significant difference in the eradication rate was found among the patients with peptic ulcer disease (n = 31) between the OAC7 group (85.7%) and OAC14 group (87.5%). However, smokers had an obviously lower eradication rate compared to non-smokers, particularly in the OAC7 group (57.1% in smokers vs 83.6% in non-smokers; P = 0.06). Adverse effects rate were similar between both groups. CONCLUSION: Short-term efficacy of triple therapy with OAC for 7 d is comparable to 14 d in this high-prevalence population. Longer follow-up, and studies focused to some subgroups of patients (smokers and non-ulcer patients) are necessary to support widespread use of 7-d instead of 10-14-d triple therapy in a developing country like Chile. (C) 2007 The WJG Press. All rights reserved. |
| Derechos | acceso abierto |
| DOI | 10.3748/wjg.v13.i21.2967 |
| Editorial | BAISHIDENG PUBLISHING GROUP INC |
| Enlace | |
| Id de publicación en Pubmed | MEDLINE:17589948 |
| Id de publicación en WoS | WOS:000247385700011 |
| Paginación | 6 páginas |
| Palabra clave | Helicobacter pylori antibiotic treatment omeprazole amoxicillin clarithromycin quasi-randomized controlled trial DUODENAL-ULCER DISEASE REINFECTION RATE RISK-FACTORS DOUBLE-BLIND AMOXICILLIN LANSOPRAZOLE CLARITHROMYCIN MULTICENTER OMEPRAZOLE MANAGEMENT |
| Tema ODS | 03 Good Health and Well-being |
| Tema ODS español | 03 Salud y bienestar |
| Tipo de documento | artículo |