Near-optimal glycemic control in Chilean women with pregestational type-2 diabetes: Persistent macrosomia relates to maternal pre-pregnancy overweight
link https://doi.org/10.1016/j.diabres.2009.04.015account_box Olmos, Pablo R.account_box Araya Del Pino, Andrea P.account_box Gonzalez Carvello, Cristian A.account_box Laso Ulloa, Pabloaccount_box Hodgson, Maria I.account_box Irribarra, Veronicaaccount_box Borzone, Gisella R.account_box Belmar, Cristianaccount_box Poblete, Andresaccount_box Berrios, Ceciliaaccount_box Becker, Jorgeaccount_box Zajer Amar, Claudia M.account_box Manzur, Alejandroaccount_box Bozinovic, Milanaccount_box Miranda, Ramon J.account_box Diez, Albertoaccount_box Vidal, Hernanaccount_box Ramirez Armijo, Renatoaccount_box Olmos, Roberto I.account_box Tabilo, Cristianaccount_box Ahuad, Jessica
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After a 10-year program intending to improve glycemic control in diabetic pregnancies, we evaluated whether factors underlying macrosomia are similar for type-1 and -2 pregestational diabetic women.
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| Autor | Olmos, Pablo R. Araya Del Pino, Andrea P. Gonzalez Carvello, Cristian A. Laso Ulloa, Pablo Hodgson, Maria I. Irribarra, Veronica Borzone, Gisella R. Belmar, Cristian Poblete, Andres Berrios, Cecilia Becker, Jorge Zajer Amar, Claudia M. Manzur, Alejandro Bozinovic, Milan Miranda, Ramon J. Diez, Alberto Vidal, Hernan Ramirez Armijo, Renato Olmos, Roberto I. Tabilo, Cristian Ahuad, Jessica |
| Título | Near-optimal glycemic control in Chilean women with pregestational type-2 diabetes: Persistent macrosomia relates to maternal pre-pregnancy overweight |
| Revista | DIABETES RESEARCH AND CLINICAL PRACTICE |
| ISSN | 0168-8227 |
| Volumen | 85 |
| Número de publicación | 1 |
| Página inicio | 53 |
| Página final | 60 |
| Fecha de publicación | 2009 |
| Resumen | After a 10-year program intending to improve glycemic control in diabetic pregnancies, we evaluated whether factors underlying macrosomia are similar for type-1 and -2 pregestational diabetic women. Patients and methods: Twenty-three pregnancies in type-1 diabetics (PDM1, age 28.3 +/- 1.1 years) and 51 pregnancies in type-2 diabetics (PDM2, age 32.8 +/- 0.6 years) were followed and treated with intensified insulin therapy. Several factors potentially influencing macrosomia were evaluated. Statistics: chi-square, Fisher's exact, Student's "t" and Mann-Whitney "U" tests, and ROC analysis. Results: In PDM1 and PDM2, respectively, large-for-gestational-age (LGA) frequencies were 26.08% and 37.25% (NS), antepartum. HbA1c values were 6.5 +/- 0.32 and 6.1 +/- 0.16 (NS), and pre-pregnancy body mass indexes (BMI) were 23.03 +/- 0.66 and 30.01 +/- 0.89 (p < 0.0001). In PDM1 the main predictor of LGA was an antepartum HbA1c >= 6.8% (p = 0.046), whereas in PDM2 pregestational BMI >= 24 the variable associated (p = 0.032) with LGA newborns. Conclusions: PDM1 and PDM2 differ in the underlying factors related to macrosomia. Whereas in PDM1 the antepartum. HbA1c emerged as the most significant variable, suggesting that glycemic control largely determines macrosomia, in PDM2 with near-optimal glycemic control, macrosomia related to pregestational BMI. (C) 2009 Elsevier Ireland Ltd. All rights reserved. |
| Derechos | acceso restringido |
| DOI | 10.1016/j.diabres.2009.04.015 |
| Editorial | ELSEVIER IRELAND LTD |
| Enlace | |
| Id de publicación en Pubmed | MEDLINE:19446354 |
| Id de publicación en WoS | WOS:000267913300010 |
| Paginación | 8 páginas |
| Palabra clave | Diabetes Pregestational Macrosomia Overweight INSULIN THERAPY PREGNANT-WOMEN BIRTH-WEIGHT MELLITUS CHALLENGE LEPTIN GROWTH LIPIDS |
| Tema ODS | 05 Gender Equality 03 Good Health and Well-being |
| Tema ODS español | 05 Igualdad de género 03 Salud y bienestar |
| Tipo de documento | artículo |