Hematologic profile of the fetus with systemic inflammatory response syndrome
link https://doi.org/10.1515/JPM.2011.100get_appHematologic profile of the fetus with systemic inflammatory response syndrome.pdf
account_box Romero, Robertoaccount_box Savasan, Zeynep Alpayaccount_box Chaiworapongsa, Tinnakornaccount_box Berry, Stanley M.account_box Pedro Kusanovic, Juanaccount_box Hassan, Sonia S.account_box Yoon, Bo Hyunaccount_box Edwin, Samuelaccount_box Mazor, Moshe
Comparte este registro
Objective: The fetal inflammatory response syndrome (FIRS) is associated with impending onset of preterm labor/delivery, microbial invasion of the amniotic cavity and increased perinatal morbidity. FIRS has been defined by an elevated fetal plasma interleukin (IL)-6, a cytokine with potent effects on the differentiation and proliferation of hematopoietic precursors. The objective of this study was to characterize the hematologic profile of fetuses with FIRS.
Registro Sencillo
Registro Completo
| Autor | Romero, Roberto Savasan, Zeynep Alpay Chaiworapongsa, Tinnakorn Berry, Stanley M. Pedro Kusanovic, Juan Hassan, Sonia S. Yoon, Bo Hyun Edwin, Samuel Mazor, Moshe |
| Título | Hematologic profile of the fetus with systemic inflammatory response syndrome |
| Revista | JOURNAL OF PERINATAL MEDICINE |
| ISSN | 0300-5577 |
| ISSN electrónico | 1619-3997 |
| Volumen | 40 |
| Número de publicación | 1 |
| Página inicio | 19 |
| Página final | 32 |
| Fecha de publicación | 2012 |
| Resumen | Objective: The fetal inflammatory response syndrome (FIRS) is associated with impending onset of preterm labor/delivery, microbial invasion of the amniotic cavity and increased perinatal morbidity. FIRS has been defined by an elevated fetal plasma interleukin (IL)-6, a cytokine with potent effects on the differentiation and proliferation of hematopoietic precursors. The objective of this study was to characterize the hematologic profile of fetuses with FIRS. Study design: Fetal blood sampling was performed in patients with preterm prelabor rupture of membranes and preterm labor with intact membranes (n = 152). A fetal plasma IL-6 concentration >= 11 pg/mL was used to define FIRS. Hemoglobin concentration, platelet count, total white blood cell (WBC) count, differential count, and nucleated red blood cell (NRBC) count were obtained. Since blood cell count varies with gestational age, the observed values were corrected for fetal age by calculating a ratio between the observed and expected mean value for gestational age. Results: 1) The prevalence of FIRS was 28.9% (44/152); 2) fetuses with FIRS had a higher median corrected WBC and corrected neutrophil count than those without FIRS (WBC: median 1.4, range 0.3-5.6, vs. median 1.1, range 0.4-2.9, P=0.001; neutrophils: median 3.6, range 0.1-57.5, vs. median 1.8, range 0.2-13.9, P<0.001); 3) neutrophilia (defined as a neutrophil count >95th centile of gestational age) was significantly more common in fetuses with FIRS than in those without FIRS (71%, 30/42, vs. 35%, 37/105; P<0.001); 4) more than two-thirds of fetuses with FIRS had neutrophilia, whereas neutropenia was present in only 4.8% (2/42); 5) FIRS was not associated with detectable changes in hemoglobin concentration, platelet, lymphocyte, monocyte, basophil or eosinophil counts; and 6) fetuses with FIRS had a median corrected NRBC count higher than those without FIRS. However, the difference did not reach statistical significance (NRBC median 0.07, range 0-1.3, vs. median 0.04, range 0-2.3, P=0.06). Conclusion: The hematologic profile of the human fetus with FIRS is characterized by significant changes in the total WBC and neutrophil counts. The NRBC count in fetuses with FIRS tends to be higher than fetuses without FIRS. |
| Derechos | registro bibliográfico |
| Agencia financiadora | Perinatology Research Branch, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT |
| DOI | 10.1515/JPM.2011.100 |
| Editorial | WALTER DE GRUYTER GMBH |
| Enlace | |
| Id de publicación en Pubmed | MEDLINE:21957997 |
| Id de publicación en WoS | WOS:000300652600003 |
| Paginación | 14 páginas |
| Palabra clave | Cordocentesis FIRS hypoxia infection neutrophil neutrophilia nucleated red blood cells neutropenia preterm labor preterm PROM white blood cell count RED-BLOOD-CELLS TUMOR-NECROSIS-FACTOR PRETERM PREMATURE RUPTURE COLONY-STIMULATING FACTOR FLUID MATRIX METALLOPROTEINASE-8 MONOCYTE CHEMOTACTIC PROTEIN-1 2ND-TRIMESTER AMNIOTIC-FLUID UMBILICAL-CORD PLASMA WHITE-MATTER LESIONS INTRAUTERINE INFECTION |
| Tema ODS | 05 Gender Equality 03 Good Health and Well-being |
| Tema ODS español | 05 Igualdad de género 03 Salud y bienestar |
| Tipo de documento | artículo |