A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM)
link https://doi.org/10.1016/j.ajog.2010.05.026account_box Romero, Robertoaccount_box Friel, Lara A.account_box Edwards, Digna R. Velezaccount_box Kusanovic, Juan Pedroaccount_box Hassan, Sonia S.account_box Mazaki Tovi, Shaliaccount_box Vaisbuch, Ediaccount_box Kim, Chong Jaiaccount_box Erez, Offeraccount_box Chaiworapongsa, Tinnakornaccount_box Pearce, Brad D.account_box Bartlett, Jacquelaineaccount_box Salisbury, Benjamin A.account_box Anant, Madan Kumaraccount_box Vovis, Gerald F.account_box Lee, Min Seobaccount_box Gomez, Ricardoaccount_box Behnke, Ernestoaccount_box Oyarzun, Enriqueaccount_box Tromp, Gerardaccount_box Williams, Scott M.account_box Menon, Ramkumar
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OBJECTIVE: We sought to determine whether maternal/fetal single-nucleotide polymorphisms (SNPs) in candidate genes are associated with preterm prelabor rupture of membranes (pPROM).
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| Autor | Romero, Roberto Friel, Lara A. Edwards, Digna R. Velez Kusanovic, Juan Pedro Hassan, Sonia S. Mazaki Tovi, Shali Vaisbuch, Edi Kim, Chong Jai Erez, Offer Chaiworapongsa, Tinnakorn Pearce, Brad D. Bartlett, Jacquelaine Salisbury, Benjamin A. Anant, Madan Kumar Vovis, Gerald F. Lee, Min Seob Gomez, Ricardo Behnke, Ernesto Oyarzun, Enrique Tromp, Gerard Williams, Scott M. Menon, Ramkumar |
| Título | A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM) |
| Revista | AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY |
| ISSN | 0002-9378 |
| ISSN electrónico | 1097-6868 |
| Volumen | 203 |
| Número de publicación | 4 |
| Fecha de publicación | 2010 |
| Resumen | OBJECTIVE: We sought to determine whether maternal/fetal single-nucleotide polymorphisms (SNPs) in candidate genes are associated with preterm prelabor rupture of membranes (pPROM). STUDY DESIGN: A case-control study was conducted in patients with pPROM (225 mothers and 155 fetuses) and 599 mothers and 628 fetuses with a normal pregnancy; 190 candidate genes and 775 SNPs were studied. Single locus/haplotype association analyses were performed; false discovery rate was used to correct for multiple testing (q(star) = 0.15). RESULTS: First, a SNP in tissue inhibitor of metalloproteinase 2 in mothers was significantly associated with pPROM (odds ratio, 2.12; 95% confidence interval, 1.47-3.07; P = .000068), and this association remained significant after correction for multiple comparisons. Second, haplotypes for Alpha 3 type IV collagen isoform precursor in the mother were associated with pPROM ( global P = .003). Third, multilocus analysis identified a 3-locus model, which included maternal SNPs in collagen type I alpha 2, defensin alpha 5 gene, and endothelin 1. CONCLUSION: DNA variants in a maternal gene involved in extracellular matrix metabolism doubled the risk of pPROM. |
| Derechos | acceso restringido |
| Agencia financiadora | Perinatology Research Branch, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES |
| DOI | 10.1016/j.ajog.2010.05.026 |
| Editorial | MOSBY-ELSEVIER |
| Enlace | |
| Id de publicación en Pubmed | MEDLINE:20673868 |
| Id de publicación en WoS | WOS:000282287000034 |
| Paginación | 30 páginas |
| Palabra clave | chorioamnionitis DNA variants extracellular matrix genetic association study genomics genotype haplotype high dimensional biology matrix metalloproteinase parturition prematurity preterm prelabor rupture of membranes single-nucleotide polymorphism TUMOR-NECROSIS-FACTOR INTERLEUKIN-1 RECEPTOR ANTAGONIST MIDTRIMESTER AMNIOTIC-FLUID FACTOR-ALPHA GENE SINGLE NUCLEOTIDE POLYMORPHISM EHLERS-DANLOS-SYNDROME FALSE DISCOVERY RATE HUMAN UTERINE CERVIX THAN-G POLYMORPHISM PREMATURE-RUPTURE |
| Tema ODS | 03 Good Health and Well-being 05 Gender Equality |
| Tema ODS español | 03 Salud y bienestar 05 Igualdad de género |
| Tipo de documento | artículo |