The Neural Basis of Decision-Making and Reward Processing in Adults with Euthymic Bipolar Disorder or Attention-Deficit/Hyperactivity Disorder (ADHD)
link https://doi.org/10.1371/journal.pone.0037306account_box Ibanez, Agustinaccount_box Cetkovich, Marceloaccount_box Petroni, Agustinaccount_box Urquina, Hugoaccount_box Baez, Sandraaccount_box Luz Gonzalez Gadea, Mariaaccount_box Esteban Kamienkowski, Juanaccount_box Torralva, Teresaaccount_box Torrente, Fernandoaccount_box Strejilevich, Sergioaccount_box Teitelbaum, Juliaaccount_box Hurtado, Estebanaccount_box Guex, Raphaelaccount_box Melloni, Margheritaaccount_box Lischinsky, Aliciaaccount_box Sigman, Marianoaccount_box Manes, Facundo
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Background: Attention-deficit/hyperactivity disorder (ADHD) and bipolar disorder (BD) share DSM-IV criteria in adults and cause problems in decision-making. Nevertheless, no previous report has assessed a decision-making task that includes the examination of the neural correlates of reward and gambling in adults with ADHD and those with BD.
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| Autor | Ibanez, Agustin Cetkovich, Marcelo Petroni, Agustin Urquina, Hugo Baez, Sandra Luz Gonzalez Gadea, Maria Esteban Kamienkowski, Juan Torralva, Teresa Torrente, Fernando Strejilevich, Sergio Teitelbaum, Julia Hurtado, Esteban Guex, Raphael Melloni, Margherita Lischinsky, Alicia Sigman, Mariano Manes, Facundo |
| Título | The Neural Basis of Decision-Making and Reward Processing in Adults with Euthymic Bipolar Disorder or Attention-Deficit/Hyperactivity Disorder (ADHD) |
| Revista | PLOS ONE |
| ISSN | 1932-6203 |
| Volumen | 7 |
| Número de publicación | 5 |
| Fecha de publicación | 2012 |
| Resumen | Background: Attention-deficit/hyperactivity disorder (ADHD) and bipolar disorder (BD) share DSM-IV criteria in adults and cause problems in decision-making. Nevertheless, no previous report has assessed a decision-making task that includes the examination of the neural correlates of reward and gambling in adults with ADHD and those with BD. Methodology/Principal Findings: We used the Iowa gambling task (IGT), a task of rational decision-making under risk (RDMUR) and a rapid-decision gambling task (RDGT) which elicits behavioral measures as well as event-related potentials (ERPs: fERN and P3) in connection to the motivational impact of events. We did not observe between-group differences for decision-making under risk or ambiguity (RDMUR and IGT); however, there were significant differences for the ERP-assessed RDGT. Compared to controls, the ADHD group showed a pattern of impaired learning by feedback (fERN) and insensitivity to reward magnitude (P3). This ERP pattern (fERN and P3) was associated with impulsivity, hyperactivity, executive function and working memory. Compared to controls, the BD group showed fERN- and P3-enhanced responses to reward magnitude regardless of valence. This ERP pattern (fERN and P3) was associated with mood and inhibitory control. Consistent with the ERP findings, an analysis of source location revealed reduced responses of the cingulate cortex to the valence and magnitude of rewards in patients with ADHD and BD. Conclusions/Significance: Our data suggest that neurophysiological (ERPs) paradigms such as the RDGT are well suited to assess subclinical decision-making processes in patients with ADHD and BD as well as for linking the cingulate cortex with action monitoring systems. |
| Derechos | registro bibliográfico |
| Agencia financiadora | Consejo Nacional de Investigaciones Cientificas y Tecnicas Foundation Instituto de Neurologia Cognitiva and Human Frontiers Program |
| DOI | 10.1371/journal.pone.0037306 |
| Editorial | PUBLIC LIBRARY SCIENCE |
| Enlace | |
| Id de publicación en Pubmed | MEDLINE:22624011 |
| Id de publicación en WoS | WOS:000305343500094 |
| Paginación | 11 páginas |
| Palabra clave | DEFICIT HYPERACTIVITY DISORDER MEDIAL FRONTAL-CORTEX SUSTAINED ATTENTION CINGULATE CORTEX VALIDITY BRAIN NEUROECONOMICS IMPULSIVITY PERFORMANCE IMPAIRMENT |
| Tema ODS | 03 Good Health and Well-being |
| Tema ODS español | 03 Salud y bienestar |
| Tipo de documento | artículo |