A Signature of Maternal Anti-Fetal Rejection in Spontaneous Preterm Birth: Chronic Chorioamnionitis, Anti-Human Leukocyte Antigen Antibodies, and C4d
link https://doi.org/10.1371/journal.pone.0016806account_box Lee, JoonHoaccount_box Romero, Robertoaccount_box Xu, Yiaccount_box Kim, Jung Sunaccount_box Topping, Vanessaaccount_box Yoo, Wonsukaccount_box Pedro Kusanovic, Juanaccount_box Chaiworapongsa, Tinnakornaccount_box Hassan, Sonia S.account_box Yoon, Bo Hyunaccount_box Kim, Chong Jai
Comparte este registro
Background: Chronic chorioamnionitis is found in more than one-third of spontaneous preterm births. Chronic chorioamnionitis and villitis of unknown etiology represent maternal anti-fetal cellular rejection. Antibody-mediated rejection is another type of transplantation rejection. We investigated whether there was evidence for antibody-mediated rejection against the fetus in spontaneous preterm birth.
Registro Sencillo
Registro Completo
| Autor | Lee, JoonHo Romero, Roberto Xu, Yi Kim, Jung Sun Topping, Vanessa Yoo, Wonsuk Pedro Kusanovic, Juan Chaiworapongsa, Tinnakorn Hassan, Sonia S. Yoon, Bo Hyun Kim, Chong Jai |
| Título | A Signature of Maternal Anti-Fetal Rejection in Spontaneous Preterm Birth: Chronic Chorioamnionitis, Anti-Human Leukocyte Antigen Antibodies, and C4d |
| Revista | PLOS ONE |
| ISSN | 1932-6203 |
| Volumen | 6 |
| Número de publicación | 2 |
| Fecha de publicación | 2011 |
| Resumen | Background: Chronic chorioamnionitis is found in more than one-third of spontaneous preterm births. Chronic chorioamnionitis and villitis of unknown etiology represent maternal anti-fetal cellular rejection. Antibody-mediated rejection is another type of transplantation rejection. We investigated whether there was evidence for antibody-mediated rejection against the fetus in spontaneous preterm birth. Methods and Findings: This cross-sectional study included women with (1) normal pregnancy and term delivery (n = 140) and (2) spontaneous preterm delivery (n = 140). We analyzed maternal and fetal sera for panel-reactive anti-HLA class I and class II antibodies, and determined C4d deposition on umbilical vein endothelium by immunohistochemistry. Maternal anti-HLA class I seropositivity in spontaneous preterm births was higher than in normal term births (48.6% vs. 32.1%, p = 0.005). Chronic chorioamnionitis was associated with a higher maternal anti-HLA class I seropositivity (p<0.01), significant in preterm and term birth. Villitis of unknown etiology was associated with increased maternal and fetal anti-HLA class I and II seropositivity (p<0.05, for each). Fetal anti-HLA seropositivity was closely related to maternal anti-HLA seropositivity in both groups (p<0.01, for each). C4d deposition on umbilical vein endothelium was more frequent in preterm labor than term labor (77.1% vs. 11.4%, p<0.001). Logistic regression analysis revealed that chronic chorioamnionitis (OR = 6.10, 95% CI 1.29-28.83), maternal anti-HLA class I seropositivity (OR = 5.90, 95% CI 1.60-21.83), and C4d deposition on umbilical vein endothelium (OR = 36.19, 95% CI 11.42-114.66) were associated with preterm labor and delivery. Conclusions: A major subset of spontaneous preterm births has a signature of maternal anti-fetal cellular and antibody-mediated rejections with links to fetal graft-versus-host disease and alloimmune reactions. |
| Derechos | registro bibliográfico |
| Agencia financiadora | Perinatology Research Branch, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, USA EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT |
| DOI | 10.1371/journal.pone.0016806 |
| Editorial | PUBLIC LIBRARY SCIENCE |
| Enlace | |
| Id de publicación en Pubmed | MEDLINE:21326865 |
| Id de publicación en WoS | WOS:000287037000022 |
| Paginación | 9 páginas |
| Palabra clave | NEONATAL ALLOIMMUNE THROMBOCYTOPENIA CLINICAL-SIGNIFICANCE ALLOGRAFT-REJECTION RECURRENT ABORTION MEDIATED REJECTION HUMORAL IMMUNITY UNKNOWN ETIOLOGY HLA ANTIBODIES PREGNANCY MECHANISMS |
| Tema ODS | 03 Good Health and Well-being |
| Tema ODS español | 03 Salud y bienestar |
| Tipo de documento | artículo |