Humoral and cellular response induced by a second booster of an inactivated SARS-CoV-2 vaccine in adults
link https://repositorio.uc.cl/handle/11534/74133account_box Melo González, Felipeaccount_box Méndez, Constanzaaccount_box Peñaloza, H.F.account_box Schultz, B.M.account_box Piña Iturbe, A.account_box Ríos, M.account_box Moreno Tapia, D.account_box Pereira Sánchez, P.account_box Leighton, D.account_box Orellana, C.account_box Covarrubias, C.account_box Gálvez, N.M.S.account_box Soto, J.A.account_box Duarte, L.F.account_box Rivera Pérez, D.account_box Vázquez, Y.account_box Cabrera, A.account_box Bustos, S.account_box Iturriaga, C.account_box Urzua, M.account_box Navarrete, M.S.account_box Rojas, Á.account_box Fasce, R.account_box Fernández, J.account_box Mora, J.account_box Ramírez, E.account_box Gaete Argel, A.account_box Acevedo, M.account_box Valiente Echeverría, F.account_box Soto Rifo, R.account_box Weiskopf, D.account_box Grifoni, A.account_box Sette, A.account_box Zeng, G.account_box Meng, W.account_box González Aramundiz, J.V.account_box González, P.A.account_box Abarca, K.account_box Bueno, S.M.account_box Kalergis, A.M.
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The SARS-CoV-2 Omicron variant has challenged the control of the COVID-19 pandemic even in highly vaccinated countries. While a second booster of mRNA vaccines improved the immunity against SARS-CoV-2, the humoral and cellular responses induced by a second booster of an inactivated SARS-CoV-2 vaccine have not been studied. In the context of a phase 3 clinical study, we report that a second booster of CoronaVac® increased the neutralizing response against the ancestral virus yet showed poor neutralization against the Omicron variant. Additionally, isolated PBMCs displayed equivalent activation of specific CD4+ T cells and IFN-γ production when stimulated with a mega-pool of peptides derived from the spike protein of the ancestral virus or the Omicron variant. In conclusion, a second booster dose of CoronaVac® does not improve the neutralizing response against the Omicron variant compared with the first booster dose, yet it helps maintaining a robust spike-specific CD4+ T cell response.
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| Autor | Melo González, Felipe Méndez, Constanza Peñaloza, H.F. Schultz, B.M. Piña Iturbe, A. Ríos, M. Moreno Tapia, D. Pereira Sánchez, P. Leighton, D. Orellana, C. Covarrubias, C. Gálvez, N.M.S. Soto, J.A. Duarte, L.F. Rivera Pérez, D. Vázquez, Y. Cabrera, A. Bustos, S. Iturriaga, C. Urzua, M. Navarrete, M.S. Rojas, Á. Fasce, R. Fernández, J. Mora, J. Ramírez, E. Gaete Argel, A. Acevedo, M. Valiente Echeverría, F. Soto Rifo, R. Weiskopf, D. Grifoni, A. Sette, A. Zeng, G. Meng, W. González Aramundiz, J.V. González, P.A. Abarca, K. Bueno, S.M. Kalergis, A.M. |
| Título | Humoral and cellular response induced by a second booster of an inactivated SARS-CoV-2 vaccine in adults |
| Revista | medRxiv |
| Fecha de publicación | 2022 |
| Resumen | The SARS-CoV-2 Omicron variant has challenged the control of the COVID-19 pandemic even in highly vaccinated countries. While a second booster of mRNA vaccines improved the immunity against SARS-CoV-2, the humoral and cellular responses induced by a second booster of an inactivated SARS-CoV-2 vaccine have not been studied. In the context of a phase 3 clinical study, we report that a second booster of CoronaVac® increased the neutralizing response against the ancestral virus yet showed poor neutralization against the Omicron variant. Additionally, isolated PBMCs displayed equivalent activation of specific CD4+ T cells and IFN-γ production when stimulated with a mega-pool of peptides derived from the spike protein of the ancestral virus or the Omicron variant. In conclusion, a second booster dose of CoronaVac® does not improve the neutralizing response against the Omicron variant compared with the first booster dose, yet it helps maintaining a robust spike-specific CD4+ T cell response. |
| Derechos | acceso abierto |
| Licencia | Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0) |
| DOI | 10.1101/2022.08.22.22279080 |
| Enlace | |
| Tema ODS | 03 Good health and well-being |
| Tema ODS español | 03 Salud y bienestar |
| Temática | Medicina y salud |
| Tipo de documento | preprint |