A nomogram for predicting complications in patients with solid tumours and seemingly stable febrile neutropenia
link https://doi.org/10.1038/bjc.2016.118account_box Jimenez Fonseca, Paulaaccount_box Carmona-Bayonas, Albertoaccount_box Matos Garcia, Ignacioaccount_box Marcos, Rosanaaccount_box Castanon, Eduardoaccount_box Antonio, Maiteaccount_box Font, Carmeaccount_box Biosca, Merceaccount_box Blasco, Anaaccount_box Lozano, Rebecaaccount_box Ramchandani, Avinashaccount_box Beato, Carmenaccount_box Martinez de Castro, Evaaccount_box Espinosa, Javieraccount_box Martinez-Garcia, Jeronimoaccount_box Ghanem, Ismaelaccount_box Hernando Cubero, Jorgeaccount_box Aragon Manrique, Isabelaccount_box Garcia Navalon, Franciscoaccount_box Sevillano, Elenaaccount_box Manzano, Aranzazuaccount_box Virizuela, Juanaccount_box Garrido, Marceloaccount_box Mondejar, Rebecaaccount_box Angeles Arcusa, Mariaaccount_box Bonilla, Yaizaaccount_box Perez, Quioniaaccount_box Gallardo, Elenaaccount_box del Carmen Soriano, Mariaaccount_box Cardona, Merceaccount_box Sanchez Lasheras, Fernandoaccount_box Jesus Cruz, Juanaccount_box Ayala, Francisco
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Background: We sought to develop and externally validate a nomogram and web-based calculator to individually predict the development of serious complications in seemingly stable adult patients with solid tumours and episodes of febrile neutropenia (FN).
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| Autor | Jimenez Fonseca, Paula Carmona-Bayonas, Alberto Matos Garcia, Ignacio Marcos, Rosana Castanon, Eduardo Antonio, Maite Font, Carme Biosca, Merce Blasco, Ana Lozano, Rebeca Ramchandani, Avinash Beato, Carmen Martinez de Castro, Eva Espinosa, Javier Martinez-Garcia, Jeronimo Ghanem, Ismael Hernando Cubero, Jorge Aragon Manrique, Isabel Garcia Navalon, Francisco Sevillano, Elena Manzano, Aranzazu Virizuela, Juan Garrido, Marcelo Mondejar, Rebeca Angeles Arcusa, Maria Bonilla, Yaiza Perez, Quionia Gallardo, Elena del Carmen Soriano, Maria Cardona, Merce Sanchez Lasheras, Fernando Jesus Cruz, Juan Ayala, Francisco |
| Título | A nomogram for predicting complications in patients with solid tumours and seemingly stable febrile neutropenia |
| Revista | British journal of cancer |
| ISSN | 0007-0920 |
| ISSN electrónico | 1532-1827 |
| Volumen | 114 |
| Número de publicación | 11 |
| Página inicio | 1191 |
| Página final | 1198 |
| Fecha de publicación | 2016 |
| Resumen | Background: We sought to develop and externally validate a nomogram and web-based calculator to individually predict the development of serious complications in seemingly stable adult patients with solid tumours and episodes of febrile neutropenia (FN). Patients and methods: The data from the FINITE study (n = 1133) and University of Salamanca Hospital (USH) FN registry (n = 296) were used to develop and validate this tool. The main eligibility criterion was the presence of apparent clinical stability, defined as events without acute organ dysfunction, abnormal vital signs, or major infections. Discriminatory ability was measured as the concordance index and stratification into risk groups. Results: The rate of infection-related complications in the FINITE and USH series was 13.4% and 18.6%, respectively. The nomogram used the following covariates: Eastern Cooperative Group (ECOG) Performance Status >= 2, chronic obstructive pulmonary disease, chronic cardiovascular disease, mucositis of grade >= 2 (National Cancer Institute Common Toxicity Criteria), monocytes <200/mm(3), and stress-induced hyperglycaemia. The nomogram predictions appeared to be well calibrated in both data sets (Hosmer-Lemeshow test, P>0.1). The concordance index was 0.855 and 0.831 in each series. Risk group stratification revealed a significant distinction in the proportion of complications. With a >= 116-point cutoff, the nomogram yielded the following prognostic indices in the USH registry validation series: 66% sensitivity, 83% specificity, 3.88 positive likelihood ratio, 48% positive predictive value, and 91% negative predictive value. Conclusions: We have developed and externally validated a nomogram and web calculator to predict serious complications that can potentially impact decision-making in patients with seemingly stable FN. |
| Derechos | acceso restringido |
| DOI | 10.1038/bjc.2016.118 |
| Enlace | |
| Id de publicación en WoS | WOS:000376431200009 |
| Palabra clave | Clinical Index of Stable Febrile Neutropenia CISNE nomogram seemingly stable patients risk prediction complications |
| Tema ODS | 03 Good Health and Well-being |
| Tema ODS español | 03 Salud y bienestar |
| Tipo de documento | artículo |