Use of Real-Time Functional Magnetic Resonance Imaging-Based Neurofeedback to Downregulate Insular Cortex in Nicotine-Addicted Smokers
link https://doi.org/10.3791/59441account_box Rana, Mohitaccount_box Ruiz, Sergioaccount_box Sanchez Corzo, Andreaaccount_box Muehleck, Axelaccount_box Eck, Sandraaccount_box Salinas, Cesaraccount_box Zamorano, Franciscoaccount_box Silva, Claudioaccount_box Rea, Massimilianoaccount_box Batra, Anilaccount_box Birbaumer, Nielsaccount_box Sitaram, Ranganatha
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It has been more than a decade since the first functional magnetic resonance imaging (fMRI)-based neurofeedback approach was successfully implemented. Since then, various studies have demonstrated that participants can learn to voluntarily control a circumscribed brain region. Consequently, real-time fMRI (rtfMRI) provided a novel opportunity to study modifications of behavior due to manipulation of brain activity. Hence, reports of rtfMRI applications to train self-regulation of brain activity and the concomitant modifications in behavioral and clinical conditions such as neurological and psychiatric disorders [e.g., schizophrenia, obsessive compulsive Disorder (OCD), stroke] have rapidly increased.
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| Autor | Rana, Mohit Ruiz, Sergio Sanchez Corzo, Andrea Muehleck, Axel Eck, Sandra Salinas, Cesar Zamorano, Francisco Silva, Claudio Rea, Massimiliano Batra, Anil Birbaumer, Niels Sitaram, Ranganatha |
| Título | Use of Real-Time Functional Magnetic Resonance Imaging-Based Neurofeedback to Downregulate Insular Cortex in Nicotine-Addicted Smokers |
| Revista | Jove-journal of visualized experiments |
| ISSN | 1940-087X |
| Número de publicación | 160 |
| Fecha de publicación | 2020 |
| Resumen | It has been more than a decade since the first functional magnetic resonance imaging (fMRI)-based neurofeedback approach was successfully implemented. Since then, various studies have demonstrated that participants can learn to voluntarily control a circumscribed brain region. Consequently, real-time fMRI (rtfMRI) provided a novel opportunity to study modifications of behavior due to manipulation of brain activity. Hence, reports of rtfMRI applications to train self-regulation of brain activity and the concomitant modifications in behavioral and clinical conditions such as neurological and psychiatric disorders [e.g., schizophrenia, obsessive compulsive Disorder (OCD), stroke] have rapidly increased. Neuroimaging studies in addiction research have shown that the anterior cingulate cortex, orbitofrontal cortex, and insular cortex are activated during the presentation of drug-associated cues. Also, activity in both left and right insular cortices have been shown to be highly correlated with drug urges when participants are exposed to craving-eliciting cues. Hence, the bilateral insula is of particular importance in researching drug urges and addiction due to its role in the representation of bodily (interoceptive) states. This study explores the use of rtfMRI neurofeedback for the reduction in blood oxygen-level dependent (BOLD) activity in bilateral insular cortices of nicotine-addicted participants. The study also tests if there are neurofeedback training-associated modifications in the implicit attitudes of participants towards nicotine-craving cues and explicit-craving behavior. |
| Derechos | acceso restringido |
| DOI | 10.3791/59441 |
| Enlace | |
| Id de publicación en WoS | WOS:000546499200129 |
| Tema ODS | 03 Good Health and Well-being |
| Tema ODS español | 03 Salud y bienestar |
| Tipo de documento | artículo |