Dietary Crocin is Protective in Pancreatic Cancer while Reducing Radiation-Induced Hepatic Oxidative Damage
link https://doi.org/10.3390/nu12061901account_box Bakshi, Hamid A.account_box Al Zoubi, Mazhar S.account_box Faruck, Hakkim L.account_box Aljabali, Alaa A. A.account_box Rabi, Firas A.account_box Hafiz, Amin A.account_box Al-Batanyeh, Khalid M.account_box Al-Trad, Bahaaaccount_box Ansari, Prawejaccount_box Nasef, Mohamed M.account_box Charbe, Nitin B.account_box Satija, Saurabhaccount_box Mehta, Meenuaccount_box Mishra, Vijayaccount_box Gupta, Gauravaccount_box Abobaker, Salemaccount_box Negi, Poonamaccount_box Azzouz, Ibrahim M.account_box Dardouri, Ashref Ali K.account_box Dureja, Harishaccount_box Prasher, Parteekaccount_box Chellappan, Dinesh K.account_box Dua, Kamalaccount_box Da Silva, Mateus Webbaaccount_box El Tanani, Mohamedaccount_box McCarron, Paul A.account_box Tambuwala, Murtaza M.
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Pancreatic cancer is one of the fatal causes of global cancer-related deaths. Although surgery and chemotherapy are standard treatment options, post-treatment outcomes often end in a poor prognosis. In the present study, we investigated anti-pancreatic cancer and amelioration of radiation-induced oxidative damage by crocin. Crocin is a carotenoid isolated from the dietary herb saffron, a prospect for novel leads as an anti-cancer agent. Crocin significantly reduced cell viability of BXPC3 and Capan-2 by triggering caspase signaling via the downregulation of Bcl-2. It modulated the expression of cell cycle signaling proteins P53, P21, P27, CDK2, c-MYC, Cyt-c and P38. Concomitantly, crocin treatment-induced apoptosis by inducing the release of cytochrome c from mitochondria to cytosol. Microarray analysis of the expression signature of genes induced by crocin showed a substantial number of genes involved in cell signaling pathways and checkpoints (723) are significantly affected by crocin. In mice bearing pancreatic tumors, crocin significantly reduced tumor burden without a change in body weight. Additionally, it showed significant protection against radiation-induced hepatic oxidative damage, reduced the levels of hepatic toxicity and preserved liver morphology. These findings indicate that crocin has a potential role in the treatment, prevention and management of pancreatic cancer.
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| Autor | Bakshi, Hamid A. Al Zoubi, Mazhar S. Faruck, Hakkim L. Aljabali, Alaa A. A. Rabi, Firas A. Hafiz, Amin A. Al-Batanyeh, Khalid M. Al-Trad, Bahaa Ansari, Prawej Nasef, Mohamed M. Charbe, Nitin B. Satija, Saurabh Mehta, Meenu Mishra, Vijay Gupta, Gaurav Abobaker, Salem Negi, Poonam Azzouz, Ibrahim M. Dardouri, Ashref Ali K. Dureja, Harish Prasher, Parteek Chellappan, Dinesh K. Dua, Kamal Da Silva, Mateus Webba El Tanani, Mohamed McCarron, Paul A. Tambuwala, Murtaza M. |
| Título | Dietary Crocin is Protective in Pancreatic Cancer while Reducing Radiation-Induced Hepatic Oxidative Damage |
| Revista | Nutrients |
| ISSN electrónico | 2072-6643 |
| Volumen | 12 |
| Número de publicación | 6 |
| Fecha de publicación | 2020 |
| Resumen | Pancreatic cancer is one of the fatal causes of global cancer-related deaths. Although surgery and chemotherapy are standard treatment options, post-treatment outcomes often end in a poor prognosis. In the present study, we investigated anti-pancreatic cancer and amelioration of radiation-induced oxidative damage by crocin. Crocin is a carotenoid isolated from the dietary herb saffron, a prospect for novel leads as an anti-cancer agent. Crocin significantly reduced cell viability of BXPC3 and Capan-2 by triggering caspase signaling via the downregulation of Bcl-2. It modulated the expression of cell cycle signaling proteins P53, P21, P27, CDK2, c-MYC, Cyt-c and P38. Concomitantly, crocin treatment-induced apoptosis by inducing the release of cytochrome c from mitochondria to cytosol. Microarray analysis of the expression signature of genes induced by crocin showed a substantial number of genes involved in cell signaling pathways and checkpoints (723) are significantly affected by crocin. In mice bearing pancreatic tumors, crocin significantly reduced tumor burden without a change in body weight. Additionally, it showed significant protection against radiation-induced hepatic oxidative damage, reduced the levels of hepatic toxicity and preserved liver morphology. These findings indicate that crocin has a potential role in the treatment, prevention and management of pancreatic cancer. |
| Derechos | acceso restringido |
| DOI | 10.3390/nu12061901 |
| Enlace | |
| Id de publicación en WoS | WOS:000553534600001 |
| Palabra clave | pancreatic cancer crocin apoptosis cell cycle radiation hepatic injury |
| Tema ODS | 03 Good Health and Well-being |
| Tema ODS español | 03 Salud y bienestar |
| Tipo de documento | artículo |