2-Methoxyestradiol inhibits progesterone-dependent tissue factor expression and activity in breast cancer cells
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Date
2010
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Abstract
2-Methoxyestradiol (2ME) is an endogenous metabolite of 17β-estradiol with antiangiogenic and antitumor properties, although its mechanisms of action remain unclear. Progestins in hormone replacement therapy increase the risk of breast cancer. Progesteron
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Keywords
2-Methoxyestradiol, Breast cancer, Progesterone receptor, STAT5, Tissue factor