Targeting LIN28: a new hope in prostate cancer theranostics
link https://doi.org/10.2217/fon-2021-0247account_box Shrivastava, Garimaaccount_box Aljabali, Alaa A. A.account_box Shahcheraghi, Seyed Hosseinaccount_box Lotfi, Marziehaccount_box Shastri, Madhur D.account_box Shukla, Shakti D.account_box Chellappan, Dinesh K.account_box Jha, Niraj Kumaraccount_box Anand, Krishnanaccount_box Dureja, Harishaccount_box Pabari, Ritesh M.account_box Mishra, Vijayaccount_box Almutary, Abdulmajeed G.account_box Alnuqaydan, Abdullah M.account_box Charbe, Nitinaccount_box Prasher, Parteekaccount_box Negi, Poonamaccount_box Goyal, Rohitaccount_box Dua, Kamalaccount_box Gupta, Gauravaccount_box Serrano-Aroca, Angelaccount_box Bahar, Bojlulaccount_box Barh, Debmalyaaccount_box Panda, Pritam Kumaraccount_box Takayama, Kazuoaccount_box Lundstorm, Kennethaccount_box McCarron, Paulaccount_box Bakshi, Hamidaccount_box Tambuwala, Murtaza M.
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The mortality and morbidity rates for prostate cancer have recently increased to alarming levels, rising higher than lung cancer. Due to a lack of drug targets and molecular probes, existing theranostic techniques are limited. Human LIN28A and its paralog LIN28B overexpression are associated with a number of tumors resulting in a remarkable increase in cancer aggression and poor prognoses. The current review aims to highlight recent work identifying the key roles of LIN28A and LIN28B in prostate cancer, and to instigate further preclinical and clinical research in this important area.
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| Autor | Shrivastava, Garima Aljabali, Alaa A. A. Shahcheraghi, Seyed Hossein Lotfi, Marzieh Shastri, Madhur D. Shukla, Shakti D. Chellappan, Dinesh K. Jha, Niraj Kumar Anand, Krishnan Dureja, Harish Pabari, Ritesh M. Mishra, Vijay Almutary, Abdulmajeed G. Alnuqaydan, Abdullah M. Charbe, Nitin Prasher, Parteek Negi, Poonam Goyal, Rohit Dua, Kamal Gupta, Gaurav Serrano-Aroca, Angel Bahar, Bojlul Barh, Debmalya Panda, Pritam Kumar Takayama, Kazuo Lundstorm, Kenneth McCarron, Paul Bakshi, Hamid Tambuwala, Murtaza M. |
| Título | Targeting LIN28: a new hope in prostate cancer theranostics |
| Revista | Future oncology |
| ISSN | 1479-6694 |
| ISSN electrónico | 1744-8301 |
| Volumen | 17 |
| Número de publicación | 29 |
| Página inicio | 3873 |
| Página final | 3880 |
| Fecha de publicación | 2021 |
| Resumen | The mortality and morbidity rates for prostate cancer have recently increased to alarming levels, rising higher than lung cancer. Due to a lack of drug targets and molecular probes, existing theranostic techniques are limited. Human LIN28A and its paralog LIN28B overexpression are associated with a number of tumors resulting in a remarkable increase in cancer aggression and poor prognoses. The current review aims to highlight recent work identifying the key roles of LIN28A and LIN28B in prostate cancer, and to instigate further preclinical and clinical research in this important area. |
| Derechos | acceso restringido |
| DOI | 10.2217/fon-2021-0247 |
| Enlace | |
| Id de publicación en WoS | WOS:000673617700001 |
| Palabra clave | biomarker LIN28A LIN28B prostate cancer theranostic |
| Tema ODS | 03 Good Health and Well-being |
| Tema ODS español | 03 Salud y bienestar |
| Tipo de documento | artículo |