Biomarkers for dementia in Latin American countries: Gaps and opportunities
link https://doi.org/10.1002/alz.12757account_box Parra, Mario A.account_box Orellana, Paulinaaccount_box Leon, Tomasaccount_box Victoria, Cabello G.account_box Henriquez, Fernandoaccount_box Gomez, Rodrigoaccount_box Avalos, Constanzaaccount_box Damian, Andresaccount_box Slachevsky, Andreaaccount_box Ibanez, Agustinaccount_box Zetterberg, Henrikaccount_box Tijms, Betty M.account_box Yokoyama, Jennifer S.account_box Pina-Escudero, Stefanie D.account_box Cochran, J. Nicholasaccount_box Matallana, Diana L.account_box Acosta, Daisyaccount_box Allegri, Ricardoaccount_box Arias-Suarez, Bianca P.account_box Barra, Bernardoaccount_box Behrens, Maria Isabelaccount_box Brucki, SoniaM. D.account_box Busatto, Geraldoaccount_box Caramelli, Pauloaccount_box Castro-Suarez, Sheilaaccount_box Contreras, Valeriaaccount_box Custodio, Niltonaccount_box Dansilio, Sergioaccount_box De la Cruz-Puebla, Myriamaccount_box de Souza, Leonardo Cruzaccount_box Diaz, Monica M.account_box Duque, Lissetteaccount_box Farias, Gonzalo A.account_box Ferreira, Sergio T.account_box Guimet, Nahuel Magrathaccount_box Kmaid, Anaaccount_box Lira, Davidaccount_box Lopera, Franciscoaccount_box Meza, Beatriz Maraccount_box Miotto, Eliane C.account_box Nitrini, Ricardoaccount_box Nunez, Albertoaccount_box O'Neill, Santiagoaccount_box Ochoa, Johnaccount_box Pintado-Caipa, Maritzaaccount_box Resende, Elisa de Paula Francaaccount_box Risacher, Shannonaccount_box Rojas, Luz Angelaaccount_box Sabaj, Valentinaaccount_box Schilling, Lucasaccount_box Sellek, Allis F.account_box Sosa, Anaaccount_box Takada, Leonel T.account_box Teixeira, Antonio L.account_box Unaucho-Pilalumbo, Marthaaccount_box Duran-Aniotz, Claudia
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Limited knowledge on dementia biomarkers in Latin American and Caribbean (LAC) countries remains a serious barrier. Here, we reported a survey to explore the ongoing work, needs, interests, potential barriers, and opportunities for future studies related to biomarkers. The results show that neuroimaging is the most used biomarker (73%), followed by genetic studies (40%), peripheral fluids biomarkers (31%), and cerebrospinal fluid biomarkers (29%). Regarding barriers in LAC, lack of funding appears to undermine the implementation of biomarkers in clinical or research settings, followed by insufficient infrastructure and training. The survey revealed that despite the above barriers, the region holds a great potential to advance dementia biomarkers research. Considering the unique contributions that LAC could make to this growing field, we highlight the urgent need to expand biomarker research. These insights allowed us to propose an action plan that addresses the recommendations for a biomarker framework recently proposed by regional experts.
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| Autor | Parra, Mario A. Orellana, Paulina Leon, Tomas Victoria, Cabello G. Henriquez, Fernando Gomez, Rodrigo Avalos, Constanza Damian, Andres Slachevsky, Andrea Ibanez, Agustin Zetterberg, Henrik Tijms, Betty M. Yokoyama, Jennifer S. Pina-Escudero, Stefanie D. Cochran, J. Nicholas Matallana, Diana L. Acosta, Daisy Allegri, Ricardo Arias-Suarez, Bianca P. Barra, Bernardo Behrens, Maria Isabel Brucki, SoniaM. D. Busatto, Geraldo Caramelli, Paulo Castro-Suarez, Sheila Contreras, Valeria Custodio, Nilton Dansilio, Sergio De la Cruz-Puebla, Myriam de Souza, Leonardo Cruz Diaz, Monica M. Duque, Lissette Farias, Gonzalo A. Ferreira, Sergio T. Guimet, Nahuel Magrath Kmaid, Ana Lira, David Lopera, Francisco Meza, Beatriz Mar Miotto, Eliane C. Nitrini, Ricardo Nunez, Alberto O'Neill, Santiago Ochoa, John Pintado-Caipa, Maritza Resende, Elisa de Paula Franca Risacher, Shannon Rojas, Luz Angela Sabaj, Valentina Schilling, Lucas Sellek, Allis F. Sosa, Ana Takada, Leonel T. Teixeira, Antonio L. Unaucho-Pilalumbo, Martha Duran-Aniotz, Claudia |
| Título | Biomarkers for dementia in Latin American countries: Gaps and opportunities |
| Revista | Alzheimers & dementia |
| ISSN | 1552-5260 |
| ISSN electrónico | 1552-5279 |
| Volumen | 19 |
| Número de publicación | 2 |
| Página inicio | 721 |
| Página final | 735 |
| Fecha de publicación | 2023 |
| Resumen | Limited knowledge on dementia biomarkers in Latin American and Caribbean (LAC) countries remains a serious barrier. Here, we reported a survey to explore the ongoing work, needs, interests, potential barriers, and opportunities for future studies related to biomarkers. The results show that neuroimaging is the most used biomarker (73%), followed by genetic studies (40%), peripheral fluids biomarkers (31%), and cerebrospinal fluid biomarkers (29%). Regarding barriers in LAC, lack of funding appears to undermine the implementation of biomarkers in clinical or research settings, followed by insufficient infrastructure and training. The survey revealed that despite the above barriers, the region holds a great potential to advance dementia biomarkers research. Considering the unique contributions that LAC could make to this growing field, we highlight the urgent need to expand biomarker research. These insights allowed us to propose an action plan that addresses the recommendations for a biomarker framework recently proposed by regional experts. |
| Derechos | acceso restringido |
| DOI | 10.1002/alz.12757 |
| Enlace | |
| Id de publicación en WoS | WOS:000853133500001 |
| Tema ODS | 03 Good Health and Well-being |
| Tema ODS español | 03 Salud y bienestar |
| Tipo de documento | artículo |