Maternal and neonatal circulating visfatin concentrations in patients with pre-eclampsia and a small-for-gestational age neonate
link https://doi.org/10.3109/14767050903572190account_box Mazaki Tovi, Shaliaccount_box Vaisbuch, Ediaccount_box Romero, Robertoaccount_box Kusanovic, Juan Pedroaccount_box Chaiworapongsa, Tinnakornaccount_box Kim, Sun Kwonaccount_box Nhan Chang, Chia Lingaccount_box Gomez, Ricardoaccount_box Savasan, Zeynep Alpayaccount_box Madan, Ichchhaaccount_box Yoon, Bo Hyunaccount_box Yeo, Lamiaccount_box Mittal, Poojaaccount_box Ogge, Giovannaaccount_box Gonzalez, Juan M.account_box Hassan, Sonia S.
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Objective. Maternal circulating visfatin concentrations are higher in patients with a small-for-gestational-age (SGA) neonate than in those who delivered an appropriate-for-gestational age (AGA) neonate or in those with pre-eclampsia. It has been proposed that enhanced transfer of visfatin from the foetal to maternal circulation may account for the high concentrations of maternal visfatin observed in patients with an SGA neonate. The aims of this study were: (1) to determine whether cord blood visfatin concentrations differ between normal neonates, SGA neonates and newborns of pre-eclamptic mothers; and (2) to assess the relationship between maternal and foetal circulating visfatin concentrations in patients with an SGA neonate and those with pre-eclampsia.
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| Autor | Mazaki Tovi, Shali Vaisbuch, Edi Romero, Roberto Kusanovic, Juan Pedro Chaiworapongsa, Tinnakorn Kim, Sun Kwon Nhan Chang, Chia Ling Gomez, Ricardo Savasan, Zeynep Alpay Madan, Ichchha Yoon, Bo Hyun Yeo, Lami Mittal, Pooja Ogge, Giovanna Gonzalez, Juan M. Hassan, Sonia S. |
| Título | Maternal and neonatal circulating visfatin concentrations in patients with pre-eclampsia and a small-for-gestational age neonate |
| Revista | JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE |
| ISSN | 1476-7058 |
| ISSN electrónico | 1476-4954 |
| Volumen | 23 |
| Número de publicación | 10 |
| Página inicio | 1119 |
| Página final | 1128 |
| Fecha de publicación | 2010 |
| Resumen | Objective. Maternal circulating visfatin concentrations are higher in patients with a small-for-gestational-age (SGA) neonate than in those who delivered an appropriate-for-gestational age (AGA) neonate or in those with pre-eclampsia. It has been proposed that enhanced transfer of visfatin from the foetal to maternal circulation may account for the high concentrations of maternal visfatin observed in patients with an SGA neonate. The aims of this study were: (1) to determine whether cord blood visfatin concentrations differ between normal neonates, SGA neonates and newborns of pre-eclamptic mothers; and (2) to assess the relationship between maternal and foetal circulating visfatin concentrations in patients with an SGA neonate and those with pre-eclampsia. Study design. This cross-sectional study included 88 pregnant women and their neonates, as well as 22 preterm neonates in the following groups: (1) 44 normal pregnant women at term and their AGA neonates; (2) 22 normotensive pregnant women and their SGA neonates; (3) 22 women with pre-eclampsia and their neonates; and (4) 22 preterm neonates delivered following spontaneous preterm labour without funisitis or histologic chorioamnionitis, matched for gestational age with infants of pre-eclamptic mothers. Maternal plasma and cord blood visfatin concentrations were determined by ELISA. Nonparametric statistics were used for analyses. Results. (1) The median visfatin concentration was lower in umbilical cord blood than in maternal circulation, in normal pregnancy, SGA and pre-eclampsia groups (p<0.001 for all comparisons); (2) the median cord blood visfatin concentrations did not differ significantly between term AGA or SGA neonates, infants of mothers with pre-eclampsia and their gestational-age-matched preterm AGA neonates; (3) maternal and cord blood visfatin concentrations correlated only in the normal term group (r=0.48, p=0.04). Conclusion. Circulating visfatin concentrations are lower in the foetal than in the maternal circulation and did not significantly differ between the study groups. Thus, it is unlikely that the foetal circulation is the source of the high maternal visfatin concentrations reported in patients with an SGA neonate. |
| Derechos | registro bibliográfico |
| Agencia financiadora | Perinatology Research Branch, Division of Intramural Research Program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, DHHS |
| DOI | 10.3109/14767050903572190 |
| Editorial | TAYLOR & FRANCIS LTD |
| Enlace | |
| Id de publicación en Pubmed | MEDLINE:20121389 |
| Id de publicación en WoS | WOS:000282081100007 |
| Paginación | 10 páginas |
| Palabra clave | Visfatin adipokines cytokine pregnancy foetal growth restriction appropriate-for-gestational age umbilical cord blood COLONY-ENHANCING FACTOR SERUM ADIPONECTIN MULTIMERS FACTOR RECEPTOR-1 CONCENTRATION FETAL MEMBRANE DISTENSION PLACENTAL GROWTH-FACTOR NORMAL-PREGNANCY SOLUBLE ENDOGLIN INSULIN-RESISTANCE ANGIOGENIC FACTORS DIABETES-MELLITUS |
| Tema ODS | 03 Good Health and Well-being |
| Tema ODS español | 03 Salud y bienestar |
| Tipo de documento | artículo |