Gallbladder disease is associated with insulin resistance in a high risk Hispanic population
link https://doi.org/10.1016/j.jhep.2006.01.026account_box Nervi, Flavioaccount_box Miquel, Juan Franciscoaccount_box Alvarez, Manuelaccount_box Ferreccio, Catterinaaccount_box Garcia Zattera, Maria Joseaccount_box Gonzalez, Robinsonaccount_box Perez Ayuso, Rosa Mariaaccount_box Rigotti, Attilioaccount_box Villarroel, Luis
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Background/Aims: We tested whether cholesterol gallstone disease (GS) is associated to insulin resistance and serum C-reactive protein (CRP) in a high risk population.
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| Autor | Nervi, Flavio Miquel, Juan Francisco Alvarez, Manuel Ferreccio, Catterina Garcia Zattera, Maria Jose Gonzalez, Robinson Perez Ayuso, Rosa Maria Rigotti, Attilio Villarroel, Luis |
| Título | Gallbladder disease is associated with insulin resistance in a high risk Hispanic population |
| Revista | JOURNAL OF HEPATOLOGY |
| ISSN | 0168-8278 |
| ISSN electrónico | 1600-0641 |
| Volumen | 45 |
| Número de publicación | 2 |
| Página inicio | 299 |
| Página final | 305 |
| Fecha de publicación | 2006 |
| Resumen | Background/Aims: We tested whether cholesterol gallstone disease (GS) is associated to insulin resistance and serum C-reactive protein (CRP) in a high risk population. Methods:This was a nested case-control study on 881 Chilean subjects that included clinical examination, abdominal ultrasound and blood chemistries. Insulin resistance was determined by the homeostasis model assessment index (IR-(HOMA)). Results: Compared to controls (n = 582), age and sex adjusted median IR-HOMA was significantly elevated in subjects with GS (n = 299) (P < 0.001). Risks of GS in subjects with insulin resistance and different body mass index (BMI) were: BMI < 25, 2.2 (1.1-4.7); BMI 25-30, 1.5 (0.9-2.5) and BMI > 30, 1.7 (1.0-2.9). Risk of GS in subjects with metabolic syndrome was 1.7 (CI, 1.2-2.5) and with fatty liver, 1.5 (1.1-2.2). Risk of GS in subjects with CRP > 1 mg/dL was 1.0 (0.7-1.7). Conclusions: GS is associated to insulin resistance, fatty liver and to metabolic syndrome, but not to serum CRP in a high risk Hispanic population. Insulin resistance could have a major role in the pathogenesis of GS favoring the production of cholesterol supersaturated bile and altering gallbladder function. (c) 2006 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved. |
| Derechos | acceso restringido |
| DOI | 10.1016/j.jhep.2006.01.026 |
| Editorial | ELSEVIER SCIENCE BV |
| Enlace | |
| Id de publicación en Pubmed | MEDLINE:16516330 |
| Id de publicación en WoS | WOS:000239545700019 |
| Paginación | 7 páginas |
| Palabra clave | cholesterol gallstones insulin resistance obesity metabolic syndrome C-reactive protein Hispanics CORONARY HEART-DISEASE BILE-ACID SYNTHESIS GLUCOSE-TOLERANCE GALLSTONE-DISEASE CHOLESTEROL CHOLELITHIASIS CHILEAN HISPANICS FATTY LIVER INFLAMMATION PREVALENCE ATHEROSCLEROSIS |
| Tema ODS | 03 Good Health and Well-being |
| Tema ODS español | 03 Salud y bienestar |
| Tipo de documento | artículo |