Method. SLE patients (ACR criteria), age epsilon 16 years, disease duration 5 years at enrolment (T0), African-American, Hispanic (Texan or Puerto Rican) or Caucasian ethnicity, from LUMINA, a longitudinal cohort, were studied. An event was defined as the presence of arterial or venous thrombosis. Time to the first thrombotic event was examined by univariable and multivariable (MV) Cox models adjusting for pertinent baseline clinical and socio-demographic variables.
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Título | Factors predictive of thrombotic events in LUMINA, a multi-ethnic cohort of SLE patients (LXXII) |
Autor | Burgos, Paula I. McGwin, Gerald, Jr. Reveille, John D. Vila, Luis M. Alarcon, Graciela S. |
Enlace | |
Revista | RHEUMATOLOGY |
Volumen | 49 |
Número de publicación | 9 |
Fecha de publicación | 2010 |
Tipo de documento | artículo |
Agencia financiadora | National Institute of Arthritis and Musculoskeletal and Skin Disease General Clinical Research Centers National Center for Research Resources (NCRR/HIH) RCMI Clinical Research Infrastructure Initiative (RCRII) Programa de Postgrado Becas Chile NATIONAL CENTER FOR RESEARCH RESOURCES NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES |
DOI | 10.1093/rheumatology/keq140 |
Derechos | acceso restringido |
Editorial | OXFORD UNIV PRESS |
ISSN | 1462-0324 |
ISSN electrónico | 1462-0332 |
Id de publicación en Pubmed | MEDLINE:20498010 |
Id de publicación en WoS | WOS:000280904400016 |
Paginación | 6 páginas |
Palabra clave | Systemic lupus erythematosus Thrombotic events Risk factors SYSTEMIC-LUPUS-ERYTHEMATOSUS 3 ETHNIC-GROUPS ANTIPHOSPHOLIPID ANTIBODIES NATURAL-HISTORY RISK-FACTORS DISEASE RELIABILITY PREVALENCE ACTIVATION |
Página final | 1725 |
Página inicio | 1720 |
Resumen | Method. SLE patients (ACR criteria), age epsilon 16 years, disease duration 5 years at enrolment (T0), African-American, Hispanic (Texan or Puerto Rican) or Caucasian ethnicity, from LUMINA, a longitudinal cohort, were studied. An event was defined as the presence of arterial or venous thrombosis. Time to the first thrombotic event was examined by univariable and multivariable (MV) Cox models adjusting for pertinent baseline clinical and socio-demographic variables. Results. A total of 643 patients were studied; mean (s.d.) age was 36.4 (12.6) years and disease duration at T0 was 1.4 (1.3) years; 90% were female. After T0, 81 (12.6%) patients had developed a thrombotic event. In the MV model, age [hazard ratio (HR) = 1.06; 95% CI 1.03, 1.08; P < 0.0001], health insurance (HR = 0.53; 95% CI 0.30, 0.94; P = 0.029), smoking (HR = 1.85; 95% CI 1.01, 3.40; P = 0.048), damage (T0) (HR = 1.44; 95% CI 1.20, 1.71; P < 0.0001), aPL (HR = 2.12; 95% CI 1.19, 3.76; P = 0.011) and glucocorticoid (highest dose) (HR = 1.01; 95% CI 1.01, 1.02; P < 0.0001) were significant. Conclusions. Age, poverty, smoking, damage accrual, aPL and higher doses of glucocorticoids were independently associated with a shorter time to the first thrombotic event; health insurance had a protective effect. Acting upon modifiable risk factors at the personal (smoking, high-dose glucocorticoids) and societal (poverty, health insurance) levels may prevent these events and improve the long-term outcome of SLE patients. |
dc.subject.ods | 03 Good Health and Well-being |
dc.subject.odspa | 03 Salud y bienestar |