Maternal Plasma Concentration of the Pro-Inflammatory Adipokine Pre-B-Cell-Enhancing Factor (PBEF)/Visfatin Is Elevated In Pregnant Patients with Acute Pyelonephritis
link https://doi.org/10.1111/j.1600-0897.2009.00804.xaccount_box Mazaki Tovi, Shaliaccount_box Vaisbuch, Ediaccount_box Romero, Robertoaccount_box Kusanovic, Juan Pedroaccount_box Chaiworapongsa, Tinnakornaccount_box Kim, Sun Kwonaccount_box Nhan Chang, Chia Lingaccount_box Gomez, Ricardoaccount_box Yoon, Bo H.account_box Yeo, Lamiaccount_box Mittal, Poojaaccount_box Ogge, Giovannaaccount_box Gonzalez, Juan M.account_box Hassan, Sonia S.
Comparte este registro
Problem
Registro Sencillo
Registro Completo
| Autor | Mazaki Tovi, Shali Vaisbuch, Edi Romero, Roberto Kusanovic, Juan Pedro Chaiworapongsa, Tinnakorn Kim, Sun Kwon Nhan Chang, Chia Ling Gomez, Ricardo Yoon, Bo H. Yeo, Lami Mittal, Pooja Ogge, Giovanna Gonzalez, Juan M. Hassan, Sonia S. |
| Título | Maternal Plasma Concentration of the Pro-Inflammatory Adipokine Pre-B-Cell-Enhancing Factor (PBEF)/Visfatin Is Elevated In Pregnant Patients with Acute Pyelonephritis |
| Revista | AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY |
| ISSN | 1046-7408 |
| ISSN electrónico | 1600-0897 |
| Volumen | 63 |
| Número de publicación | 3 |
| Página inicio | 252 |
| Página final | 262 |
| Fecha de publicación | 2010 |
| Resumen | Problem Visfatin/pre-B-cell-enhancing factor (PBEF) has been implicated in the regulation of the innate immune system, as well as in glucose metabolism. Specifically, visfatin plays a requisite role in delayed neutrophil apoptosis in patients with sepsis. The aim of this study was to determine whether pyelonephritis during pregnancy is associated with changes in maternal plasma visfatin concentration in normal weight and overweight/obese patients. Method of study This cross-sectional study included the following groups: (1) normal pregnant women (n = 200) and (2) pregnant women with pyelonephritis (n = 40). Maternal plasma visfatin concentrations were determined by ELISA. Non-parametric statistics was used for analyses. Results (1) The median maternal plasma visfatin concentration was significantly higher in patients with pyelonephritis than in those with a normal pregnancy; (2) among overweight/obese pregnant women, those with pyelonephritis had a significantly higher median plasma visfatin concentration than women with a normal pregnancy; and (3) pyelonephritis was independently associated with higher maternal plasma visfatin concentrations after adjustment for maternal age, pre-gestational body mass index, smoking status, gestational age at sampling, and birthweight. Conclusion Acute pyelonephritis during pregnancy is associated with a high circulating maternal visfatin concentration. These findings suggest that visfatin/PBEF may play a role in the regulation of the complex and dynamic crosstalk between inflammation and metabolism during pregnancy. |
| Derechos | acceso restringido |
| Agencia financiadora | EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT Intramural NIH HHS |
| DOI | 10.1111/j.1600-0897.2009.00804.x |
| Editorial | WILEY |
| Enlace | |
| Id de publicación en Pubmed | MEDLINE:20085562 |
| Id de publicación en WoS | WOS:000274388000011 |
| Paginación | 11 páginas |
| Palabra clave | Acute bacterial infection adipokines BMI cytokine infection inflammation maternal obesity overweight pregnancy urinary tract infection SERUM ADIPONECTIN MULTIMERS FACTOR GENE POLYMORPHISMS VISFATIN CONCENTRATIONS AMNIOTIC-FLUID ADIPOSE-TISSUE GESTATIONAL-AGE INSULIN-RESISTANCE IMMUNE-RESPONSE MESSENGER-RNA LEPTIN LEVELS |
| Tema ODS | 03 Good Health and Well-being |
| Tema ODS español | 03 Salud y bienestar |
| Tipo de documento | artículo |