DETERMINATION OF THE RATES OF FORMATION AND HYDROLYSIS OF THE SCHIFF-BASES FORMED BY PYRIDOXAL 5'-PHOSPHATE AND COPOLYPEPTIDES CONTAINING L-LYSINE
link https://repositorio.uc.cl/handle/11534/78159account_box ANGELES, Maccount_box DELVADO, Gaccount_box ECHEVARRIA, GRaccount_box BLANCO, JGSaccount_box BLANCO, FG
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We determined the apparent rate constants of formation (k1) and hydrolysis (k2) of the Schiff bases formed between pyridoxal 5'-phosphate (PLP) and L-lysine and L-alanine copolymers of different compositions, as well as those formed between PLP and L-lysine and L-glutamic acid copolymers, at various pH values, a temperature of 25-degrees-C and an ionic strength of 0.1 M. The k1 values obtained in neutral and acidic media were independent of the copolymer composition. The efficiency of the intramolecular acid catalysis for the formation of the Schiff bases was found to be somewhat higher than that of PLP-primary amine systems (the slope of the Bronsted plot was alpha=0.77). The most stable of the Schiff bases studied was that with a protonated imine nitrogen and phosphate group and an unprotonated pyridine nitrogen.
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| Autor | ANGELES, M DELVADO, G ECHEVARRIA, GR BLANCO, JGS BLANCO, FG |
| Título | DETERMINATION OF THE RATES OF FORMATION AND HYDROLYSIS OF THE SCHIFF-BASES FORMED BY PYRIDOXAL 5'-PHOSPHATE AND COPOLYPEPTIDES CONTAINING L-LYSINE |
| Revista | JOURNAL OF MOLECULAR CATALYSIS |
| ISSN | 0304-5102 |
| Volumen | 78 |
| Número de publicación | 3 |
| Página inicio | 379 |
| Página final | 387 |
| Fecha de publicación | 1993 |
| Resumen | We determined the apparent rate constants of formation (k1) and hydrolysis (k2) of the Schiff bases formed between pyridoxal 5'-phosphate (PLP) and L-lysine and L-alanine copolymers of different compositions, as well as those formed between PLP and L-lysine and L-glutamic acid copolymers, at various pH values, a temperature of 25-degrees-C and an ionic strength of 0.1 M. The k1 values obtained in neutral and acidic media were independent of the copolymer composition. The efficiency of the intramolecular acid catalysis for the formation of the Schiff bases was found to be somewhat higher than that of PLP-primary amine systems (the slope of the Bronsted plot was alpha=0.77). The most stable of the Schiff bases studied was that with a protonated imine nitrogen and phosphate group and an unprotonated pyridine nitrogen. |
| Derechos | registro bibliográfico |
| Editorial | ELSEVIER SCIENCE BV |
| Enlace | |
| Id de publicación en WoS | WOS:A1993KQ71200017 |
| Paginación | 9 páginas |
| Palabra clave | NORMAL-HEXYLAMINE THERMODYNAMIC PARAMETERS GLYCOGEN-PHOSPHORYLASE N-HEXYLAMINE PYRIDOXAL-5'-PHOSPHATE 5'-DEOXYPYRIDOXAL CATALYSIS EQUILIBRIA STABILITY POLARITY |
| Tema ODS | 03 Good Health and Well-being 12 Responsible Consumption and Production |
| Tema ODS español | 03 Salud y bienestar 12 Producción y consumo responsable |
| Tipo de documento | artículo |