Synthesis and Antitumor Evaluation of Thiophene Analogs of Kigelinone
link https://doi.org/10.2174/157017809788490006get_app2024-05-23. Synthesis and Antitumor Evaluation of Thiophene Analogs of Kigelinone.pdf
account_box Valderrama, Jaime A.account_box Espinoza, Omaraccount_box Rodriguez, Jaimeaccount_box Theoduloz, Cristina
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The synthesis of kigelinone thiophene analogs and related naphtho[2,3-b] thiophene-4,9-quinones from 2-substituted 4,7-dimethoxybenzo[b]thiophenes via an oxidative deprotection, Diels-Alder, and oxidative aromatization reaction sequence is reported. The 2-substituted naphtho[2,3-b] thiophene-4,9-quinones display significant antitumor activity in the range IC50 1.1-47 mu M on a panel of four distinct human cancer cell lines.
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| Autor | Valderrama, Jaime A. Espinoza, Omar Rodriguez, Jaime Theoduloz, Cristina |
| Título | Synthesis and Antitumor Evaluation of Thiophene Analogs of Kigelinone |
| Revista | LETTERS IN ORGANIC CHEMISTRY |
| ISSN | 1570-1786 |
| ISSN electrónico | 1875-6255 |
| Volumen | 6 |
| Número de publicación | 4 |
| Página inicio | 278 |
| Página final | 281 |
| Fecha de publicación | 2009 |
| Resumen | The synthesis of kigelinone thiophene analogs and related naphtho[2,3-b] thiophene-4,9-quinones from 2-substituted 4,7-dimethoxybenzo[b]thiophenes via an oxidative deprotection, Diels-Alder, and oxidative aromatization reaction sequence is reported. The 2-substituted naphtho[2,3-b] thiophene-4,9-quinones display significant antitumor activity in the range IC50 1.1-47 mu M on a panel of four distinct human cancer cell lines. |
| Derechos | acceso restringido |
| Agencia financiadora | Fondo Nacional de Ciencia y Tecnologia |
| DOI | 10.2174/157017809788490006 |
| Editorial | BENTHAM SCIENCE PUBL LTD |
| Enlace | |
| Id de publicación en WoS | WOS:000267046600003 |
| Paginación | 4 páginas |
| Palabra clave | Quinones Benzo[b]thiophenes Oxidative deprotection Diels-Alder reaction Regioisomers Citotoxicity LEISHMANICIDAL ACTIVITY ANTIPROTOZOAL ACTIVITY TABEBUIA-AVELLANEDAE QUINONES CYTOTOXICITY FURANONAPHTHOQUINONES HYDROQUINONES RING |
| Tema ODS | 03 Good Health and Well-being |
| Tema ODS español | 03 Salud y bienestar |
| Tipo de documento | artículo |