Solubility of 1,3-Dimethyl-7H-purine-2,6-dione (Theophylline) in Supercritical Carbon Dioxide
link https://doi.org/10.1021/je900099maccount_box de la Fuente, Juan C.account_box Nunez, Gonzaloaccount_box del Valle, Jose M.
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This contribution provides complementary experimental data of solubility (y(2), molar fraction) of solid 1,3-dimethyl-7H-purine-2,6-dione (theophylline) in supercritical CO2 as a function of temperature (313 K <= T <= 333 K) and pressure (10 MPa <= P <= 44 MPa). A static-analytic methodology was used with standard deviations from average solubility measurements of <= 38% and with estimated inherit errors <= 25%. The solubility of theophylline increased with the CO2 density from 0.33.10(-5) mol.mol(-1) at 797.2 kg.m(-3) (313 K, 16 MPa) to 3.3.10(-5) mol.mol(-1) at 890.2 kg.m(-3) (333 K, 40 MPa). The solubility increased with pressure and temperature. Experimental solubilities were correlated with a density-based model with three adjustable parameters, which was valid for solvent densities in the range of (400 to 950) kg.m(-3).
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| Autor | de la Fuente, Juan C. Nunez, Gonzalo del Valle, Jose M. |
| Título | Solubility of 1,3-Dimethyl-7H-purine-2,6-dione (Theophylline) in Supercritical Carbon Dioxide |
| Revista | JOURNAL OF CHEMICAL AND ENGINEERING DATA |
| ISSN | 0021-9568 |
| Volumen | 54 |
| Número de publicación | 11 |
| Página inicio | 3034 |
| Página final | 3036 |
| Fecha de publicación | 2009 |
| Resumen | This contribution provides complementary experimental data of solubility (y(2), molar fraction) of solid 1,3-dimethyl-7H-purine-2,6-dione (theophylline) in supercritical CO2 as a function of temperature (313 K <= T <= 333 K) and pressure (10 MPa <= P <= 44 MPa). A static-analytic methodology was used with standard deviations from average solubility measurements of <= 38% and with estimated inherit errors <= 25%. The solubility of theophylline increased with the CO2 density from 0.33.10(-5) mol.mol(-1) at 797.2 kg.m(-3) (313 K, 16 MPa) to 3.3.10(-5) mol.mol(-1) at 890.2 kg.m(-3) (333 K, 40 MPa). The solubility increased with pressure and temperature. Experimental solubilities were correlated with a density-based model with three adjustable parameters, which was valid for solvent densities in the range of (400 to 950) kg.m(-3). |
| Derechos | acceso restringido |
| Agencia financiadora | Chilean agency Fondecyt |
| DOI | 10.1021/je900099m |
| Editorial | AMER CHEMICAL SOC |
| Enlace | |
| Id de publicación en WoS | WOS:000271579800010 |
| Paginación | 3 páginas |
| Palabra clave | LIQUID-CHROMATOGRAPHY PHASE-BEHAVIOR THEOBROMINE CAFFEINE CO2 |
| Tipo de documento | artículo |