Association between leptin receptor (LEPR) and brain-derived neurotrophic factor (BDNF) gene variants and obesity: a case-control study
link https://doi.org/10.1179/147683009X423355account_box Marti, A.account_box Santos, J. L.account_box Gratacos, M.account_box Moreno Aliaga, M. J.account_box Maiz, A.account_box Martinez, J. A.account_box Estivill, X.
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Introduction: Human and animal studies provide evidence for a relevant role of the leptin receptor (LEPR) and the brain-derived neurotrophic factor (BDNF) genes in energy homeostasis.
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| Autor | Marti, A. Santos, J. L. Gratacos, M. Moreno Aliaga, M. J. Maiz, A. Martinez, J. A. Estivill, X. |
| Título | Association between leptin receptor (LEPR) and brain-derived neurotrophic factor (BDNF) gene variants and obesity: a case-control study |
| Revista | NUTRITIONAL NEUROSCIENCE |
| ISSN | 1028-415X |
| ISSN electrónico | 1476-8305 |
| Volumen | 12 |
| Número de publicación | 4 |
| Página inicio | 183 |
| Página final | 188 |
| Fecha de publicación | 2009 |
| Resumen | Introduction: Human and animal studies provide evidence for a relevant role of the leptin receptor (LEPR) and the brain-derived neurotrophic factor (BDNF) genes in energy homeostasis. Aim: To assess the association between human LEPR and BDNF genetic variants with adult obesity. Design and methods: Case-control study in Pamplona (Navarra, Spain) with adult obese subjects (n = 159) and normal weight controls (n = 154) Four common polymorphisms of the LEPR gene (Lys109Arg, Gln223Arg, Ser34Ser, Lys656Asn) and 17 variants of the BDNF gene, including the Val66Met variant, were genotyped. Results: No significant case-control differences were found in allele/genotype frequencies after adjusting for relevant co-variates. Haplotype analysis did not detect any significant association between LEPR or BDNF variants and obesity. No associations were found between LEPR variants and serum leptin levels. Conclusions: Our results do not support a major role of LEPR or BDNF common polymorphisms in multifactorial adult obesity. |
| Derechos | acceso restringido |
| DOI | 10.1179/147683009X423355 |
| Editorial | TAYLOR & FRANCIS LTD |
| Enlace | |
| Id de publicación en Pubmed | MEDLINE:19622243 |
| Id de publicación en WoS | WOS:000267975700007 |
| Paginación | 6 páginas |
| Palabra clave | obesity leptin receptor brain-derived neurotrophic factor case-control study BODY-MASS INDEX ANOREXIA-NERVOSA WEIGHT RISK SPECTRUM EXTREME LINKAGE GAIN |
| Tema ODS | 03 Good Health and Well-being 02 Zero Hunger |
| Tema ODS español | 03 Salud y bienestar 02 Hambre cero |
| Tipo de documento | artículo |