SARS-CoV-2 spike protein S1 activates Cx43 hemichannels and disturbs intracellular Ca2+ dynamics
link https://doi.org/10.1186/s40659-023-00468-9account_box Prieto Villalobos, Juan Carlosaccount_box Lucero, Claudia M.account_box Rovegno, Maximilianoaccount_box Gómez, Gonzalo I.account_box Retamal, Mauricio A.account_box Orellana Roca, Juan Andrés
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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes the ongoing coronavirus disease 2019 (COVID-19). An aspect of high uncertainty is whether the SARS-CoV-2 per se or the systemic inflammation induced by viral infection directly affects cellular function and survival in different tissues. It has been postulated that tissue dysfunction and damage observed in COVID-19 patients may rely on the direct effects of SARS-CoV-2 viral proteins. Previous evidence indicates that the human immunodeficiency virus and its envelope protein gp120 increase the activity of connexin 43 (Cx43) hemichannels with negative repercussions for cellular function and survival. Here, we evaluated whether the spike protein S1 of SARS-CoV-2 could impact the activity of Cx43 hemichannels.
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| Autor | Prieto Villalobos, Juan Carlos Lucero, Claudia M. Rovegno, Maximiliano Gómez, Gonzalo I. Retamal, Mauricio A. Orellana Roca, Juan Andrés |
| Título | SARS-CoV-2 spike protein S1 activates Cx43 hemichannels and disturbs intracellular Ca2+ dynamics |
| Revista | Biological Research |
| ISSN | 0717-6287 |
| Número de publicación | 56 |
| Página inicio | 1 |
| Página final | 14 |
| Fecha de publicación | 2023 |
| Resumen | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes the ongoing coronavirus disease 2019 (COVID-19). An aspect of high uncertainty is whether the SARS-CoV-2 per se or the systemic inflammation induced by viral infection directly affects cellular function and survival in different tissues. It has been postulated that tissue dysfunction and damage observed in COVID-19 patients may rely on the direct effects of SARS-CoV-2 viral proteins. Previous evidence indicates that the human immunodeficiency virus and its envelope protein gp120 increase the activity of connexin 43 (Cx43) hemichannels with negative repercussions for cellular function and survival. Here, we evaluated whether the spike protein S1 of SARS-CoV-2 could impact the activity of Cx43 hemichannels. |
| Derechos | acceso abierto |
| DOI | 10.1186/s40659-023-00468-9 |
| Enlace | |
| Id de publicación en WoS | WOS:001088630300002 |
| Paginación | 14 páginas |
| Palabra clave | Hemichannels COVID-19 Connexin 43 SARS-CoV-2 |
| Tema ODS | 03 Good health and well-being |
| Tema ODS español | 03 Salud y bienestar |
| Temática | Medicina y salud |
| Tipo de documento | artículo |