HACEK Infective Endocarditis: Characteristics and Outcomes from a Large, Multi-National Cohort
link https://doi.org/10.1371/journal.pone.0063181account_box Chambers, Stephen T.account_box Murdoch, Davidaccount_box Morris, Arthuraccount_box Holland, Davidaccount_box Pappas, Paulaccount_box Almela, Manelaccount_box Fernandez-Hidalgo, Nuriaaccount_box Almirante, Benitoaccount_box Bouza, Emilioaccount_box Forno, Davideaccount_box del Rio, Anaaccount_box Hannan, Margaret M.account_box Harkness, Johnaccount_box Kanafani, Zeina A.account_box Lalani, Tahaniyataccount_box Lang, Selwynaccount_box Raymond, Nigelaccount_box Read, Kerryaccount_box Vinogradova, Tatianaaccount_box Woods, Christopher W.account_box Wray, Dannahaccount_box Corey, G. Ralphaccount_box Chu, Vivian H.account_box Clara, Lilianaaccount_box Sanchez, Marisaaccount_box Nacinovich, Franciscoaccount_box Fernandez Oses, Pabloaccount_box Ronderos, Ricardoaccount_box Sucari, Adrianaaccount_box Thierer, Jorgeaccount_box Casabe, Joseaccount_box Cortes, Claudiaaccount_box Altclas, Javieraccount_box Kogan, Silviaaccount_box Spelman, Denisaccount_box Athan, Eugeneaccount_box Harris, Owenaccount_box Kennedy, Karinaaccount_box Tan, Renaccount_box Gordon, Davidaccount_box Papanicolas, Litoaccount_box Eisen, Damonaccount_box Grigg, Leeanneaccount_box Street, Alanaccount_box Korman, Tonyaccount_box Kotsanas, Despinaaccount_box Dever, Robynaccount_box Jones, Phillipaccount_box Konecny, Pamaccount_box Lawrence, Richardaccount_box Rees, Davidaccount_box Ryan, Suzanneaccount_box Feneley, Michael P.account_box Harkness, Johnaccount_box Jones, Phillipaccount_box Ryan, Suzanneaccount_box Jones, Phillipaccount_box Ryan, Suzanneaccount_box Jones, Phillipaccount_box Post, Jeffreyaccount_box Reinbott, Porlaccount_box Ryan, Suzanneaccount_box Gattringer, Raineraccount_box Wiesbauer, Franzaccount_box Andrade, Adriana Ribasaccount_box Passos de Brito, Ana Claudiaaccount_box Guimaraes, Armenio Costaaccount_box Grinberg, Maxaccount_box Mansur, Alfredo Joseaccount_box Siciliano, Rinaldo Focacciaaccount_box Varejao Strabelli, Tania Maraaccount_box Campos Vieira, Marcelo Luizaccount_box de Medeiros Tranchesi, Regina Aparecidaaccount_box Paiva, Marcelo Goulartaccount_box Fortes, Claudio Queridoaccount_box Ramos, Auristela de Oliveiraaccount_box Ferraiuoli, Giovannaaccount_box Golebiovski, Wilmaaccount_box Lamas, Cristianeaccount_box Santos, Marisaaccount_box Weksler, Claraaccount_box Karlowsky, James A.account_box Keynan, Yoavaccount_box Morris, Andrew M.account_box Rubinstein, Ethanaccount_box Jones, Sandra Braunaccount_box Garcia, Patriciaaccount_box Cereceda, M.account_box Fica, Albertoaccount_box Mella, Rodrigo Montagnaaccount_box Barsic, Brunoaccount_box Bukovski, Suzanaaccount_box Krajinovic, Vladimiraccount_box Pangercic, Anaaccount_box Rudez, Igoraccount_box Vincelj, Josipaccount_box Freiberger, Tomasaccount_box Pol, Jiriaccount_box Zaloudikova, Barboraaccount_box Ashour, Zainabaccount_box El Kholy, Amaniaccount_box Mishaal, Marwaaccount_box Rizk, Hussienaccount_box Aissa, Neijlaaccount_box Alauzet, Corentineaccount_box Alla, Francoisaccount_box Campagnac, Catherineaccount_box Doco-Lecompte, Thanhaccount_box Selton-Suty, Christineaccount_box Casalta, Jean-Paulaccount_box Fournier, Pierre-Edouardaccount_box Habib, Gilbertaccount_box Raoult, Didieraccount_box Thuny, Franckaccount_box Delahaye, Francoisaccount_box Delahaye, Armelleaccount_box Vandenesch, Francoisaccount_box Donal, Erwanaccount_box Donnio, Pierre Yvesaccount_box Michelet, Christianaccount_box Revest, Matthieuaccount_box Tattevin, Pierreaccount_box Violette, Jeremieaccount_box Chevalier, Florentaccount_box Jeu, Antoineaccount_box Danaccount_box Rusinaruaccount_box Sorel, Claireaccount_box Tribouilloy, Christopheaccount_box Bernard, Yvetteaccount_box Chirouze, Catherineaccount_box Hoen, Brunoaccount_box Leroy, Joelaccount_box Plesiat, Patrickaccount_box Naber, Christophaccount_box Neuerburg, Carlaccount_box Mazaheri, Bahramaccount_box Naber, Christophaccount_box Neuerburg, Carlaccount_box Athanasia, Sofiaaccount_box Giannitsioti, Efthymiaaccount_box Mylona, Elenaaccount_box Paniara, Olgaaccount_box Papanicolaou, Konstantinosaccount_box Pyros, Johnaccount_box Skoutelis, Athanasiosaccount_box Sharma, Gautamaccount_box Francis, Johnsonaccount_box Nair, Lathiaccount_box Thomas, Vinodaccount_box Venugopal, Krishnanaccount_box Hannan, Margaretaccount_box Hurley, Johnaccount_box Gilon, Danaccount_box Israel, Sarahaccount_box Korem, Mayaaccount_box Strahilevitz, Jacobaccount_box Rubinstein, Ethanaccount_box Strahilevitz, Jacobaccount_box Tripodi, Marie Francoiseaccount_box Casillo, Robertaaccount_box Cuccurullo, Susannaaccount_box Dialetto, Giovanniaccount_box Durante-Mangoni, Emanueleaccount_box Irene, Mattucciaccount_box Ragone, Enricoaccount_box Utili, Riccardoaccount_box Cecchi, Enricoaccount_box De Rosa, Francescoaccount_box Forno, Davideaccount_box Imazio, Massimoaccount_box Trinchero, Ritaaccount_box Tebini, Alessandroaccount_box Grossi, Paoloaccount_box Lattanzio, Mariangelaaccount_box Toniolo, Antonioaccount_box Goglio, Antonioaccount_box Raglio, Annibaleaccount_box Ravasio, Veronicaaccount_box Rizzi, Marcoaccount_box Suter, Fredyaccount_box Carosi, Giampieroaccount_box Magri, Silviaaccount_box Signorini, Lianaaccount_box Baban, Taniaaccount_box Kanafani, Zeinaaccount_box Kanj, Souha S.account_box Sfeir, Jadaccount_box Yasmine, Mohamadaccount_box Abidin, Imranaccount_box Tamin, Syahidah Syedaccount_box Martinez, Eduardo Riveraaccount_box Nieto, Gabriel Israel Sotoaccount_box van der Meer, Jan T. M.account_box Chambers, Stephenaccount_box Holland, Davidaccount_box Morris, Arthuraccount_box Raymond, Nigelaccount_box Read, Kerryaccount_box Murdoch, David R.account_box Dragulescu, Stefanaccount_box Ionac, Adinaaccount_box Mornos, Cristianaccount_box Butkevich, O. M.account_box Chipigina, Nataliaaccount_box Kirill, Ozereckyaccount_box Vadim, Kulichenkoaccount_box Vinogradova, Tatianaaccount_box Edathodu, Jameelaaccount_box Halim, Magidaccount_box Lum, Luh-Nahaccount_box Tan, Ru-Sanaccount_box Lejko-Zupanc, Tatjanaaccount_box Logar, Matejaaccount_box Mueller-Premru, Manicaaccount_box Commerford, Patrickaccount_box Commerford, Anitaaccount_box Deetlefs, Eduanaccount_box Hansa, Cassaccount_box Ntsekhe, Mpikoaccount_box Almela, Manuelaccount_box Armero, Yolandaaccount_box Azqueta, Manuelaccount_box Castaneda, Ximenaaccount_box Cervera, Carlosaccount_box del Rio, Anaaccount_box Falces, Carlosaccount_box Garcia-de-la-Maria, Cristinaaccount_box Fita, Guillerminaaccount_box Gatell, Jose M.account_box Marco, Francescaccount_box Mestres, Carlos A.account_box Miro, Jose M.account_box Moreno, Asuncionaccount_box Ninot, Salvadoraccount_box Pare, Carlosaccount_box Pericas, Joanaccount_box Ramirez, Joseaccount_box Rovira, Ireneaccount_box Sitges, Martaaccount_box Anguera, Ignasiaccount_box Font, Bernataccount_box Guma, Joan Raimonaccount_box Bermejo, Javieraccount_box Bouza, Emilioaccount_box Garcia Fernandez, Miguel Angelaccount_box Gonzalez-Ramallo, Victoraccount_box Marin, Mercedesaccount_box Munoz, Patriciaaccount_box Pedromingo, Miguelaccount_box Roda, Jorgeaccount_box Rodriguez-Creixems, Martaaccount_box Solis, Jorgeaccount_box Almirante, Benitoaccount_box Fernandez-Hidalgo, Nuriaaccount_box Tornos, Pilaraccount_box de Alarcon, Aristidesaccount_box Parra, Ricardoaccount_box Alestig, Ericaccount_box Johansson, Magnusaccount_box Olaison, Larsaccount_box Snygg-Martin, Ulrikaaccount_box Pachirat, Orathaiaccount_box Pachirat, Pimchitraaccount_box Pussadhamma, Burabhaaccount_box Senthong, Vichaiaccount_box Casey, Annaaccount_box Elliott, Tomaccount_box Lambert, Peteraccount_box Watkin, Richardaccount_box Eyton, Christinaaccount_box Klein, John L.account_box Bradley, Suzanneaccount_box Kauffman, Carolaccount_box Bedimo, Rogeraccount_box Chu, Vivian H.account_box Corey, G. Ralphaccount_box Crowley, Anna Lisaaccount_box Douglas, Pamelaaccount_box Drew, Lauraaccount_box Fowler, Vance G.account_box Holland, Thomasaccount_box Lalani, Tahaniyataccount_box Mudrick, Danielaccount_box Samad, Zaniabaccount_box Sexton, Danielaccount_box Stryjewski, Martinaccount_box Wang, Andrewaccount_box Woods, Christopher W.account_box Lerakis, Stamatiosaccount_box Cantey, Robertaccount_box Steed, Lisaaccount_box Wray, Dannahaccount_box Dickerman, Stuart A.account_box Bonilla, Hectoraccount_box DiPersio, Josephaccount_box Salstrom, Sara-Janeaccount_box Baddley, Johnaccount_box Patel, Mukeshaccount_box Peterson, Gailaccount_box Stancoven, Amyaccount_box Afonso, Luisaccount_box Kulman, Theresaaccount_box Levine, Donaldaccount_box Rybak, Michaelaccount_box Cabell, Christopher H.account_box Baloch, Khaulaaccount_box Chu, Vivian H.account_box Corey, G. Ralphaccount_box Dixon, Christy C.account_box Fowler, Vance G.account_box Harding, Tinaaccount_box Jones-Richmond, Marianaccount_box Pappas, Paulaccount_box Park, Lawrence P.account_box Redick, Thomasaccount_box Stafford, Judyaccount_box Anstrom, Kevinaccount_box Athan, Eugeneaccount_box Bayer, Arnold S.account_box Cabell, Christopher H.account_box Chu, Vivian H.account_box Corey, G. Ralphaccount_box Fowler, Vance G.account_box Hoen, Brunoaccount_box Karchmer, A. W.account_box Miro, Jose M.account_box Murdoch, David R.account_box Sexton, Daniel J.account_box Wang, Andrewaccount_box Bayer, Arnold S.account_box Cabell, Christopher H.account_box Chu, Vivianaccount_box Corey, G. Ralphaccount_box Durack, David T.account_box Phil, D.account_box Eykyn, Susannahaccount_box Fowler, Vance G.account_box Hoen, Brunoaccount_box Miro, Jose M.account_box Moreillon, Phillipeaccount_box Olaison, Larsaccount_box Raoult, Didieraccount_box Rubinstein, Ethanaccount_box Sexton, Daniel J.
Comparte este registro
The HACEK organisms (Haemophilus species, Aggregatibacter species, Cardiobacterium hominis, Eikenella corrodens, and Kingella species) are rare causes of infective endocarditis (IE). The objective of this study is to describe the clinical characteristics and outcomes of patients with HACEK endocarditis (HE) in a large multi-national cohort. Patients hospitalized with definite or possible infective endocarditis by the International Collaboration on Endocarditis Prospective Cohort Study in 64 hospitals from 28 countries were included and characteristics of HE patients compared with IE due to other pathogens. Of 5591 patients enrolled, 77 (1.4%) had HE. HE was associated with a younger age (47 vs. 61 years; p < 0.001), a higher prevalence of immunologic/vascular manifestations (32% vs. 20%; p < 0.008) and stroke (25% vs. 17% p = 0.05) but a lower prevalence of congestive heart failure (15% vs. 30%; p = 0.004), death in-hospital (4% vs. 18%; p = 0.001) or after 1 year follow-up (6% vs. 20%; p = 0.01) than IE due to other pathogens (n = 5514). On multivariable analysis, stroke was associated with mitral valve vegetations (OR 3.60; CI 1.34-9.65; p < 0.01) and younger age (OR 0.62; CI 0.49-0.90; p < 0.01). The overall outcome of HE was excellent with the in-hospital mortality (4%) significantly better than for non-HE (18%; p < 0.001). Prosthetic valve endocarditis was more common in HE (35%) than non-HE (24%). The outcome of prosthetic valve and native valve HE was excellent whether treated medically or with surgery. Current treatment is very successful for the management of both native valve prosthetic valve HE but further studies are needed to determine why HE has a predilection for younger people and to cause stroke. The small number of patients and observational design limit inferences on treatment strategies. Self selection of study sites limits epidemiological inferences.
Registro Sencillo
Registro Completo
| Autor | Chambers, Stephen T. Murdoch, David Morris, Arthur Holland, David Pappas, Paul Almela, Manel Fernandez-Hidalgo, Nuria Almirante, Benito Bouza, Emilio Forno, Davide del Rio, Ana Hannan, Margaret M. Harkness, John Kanafani, Zeina A. Lalani, Tahaniyat Lang, Selwyn Raymond, Nigel Read, Kerry Vinogradova, Tatiana Woods, Christopher W. Wray, Dannah Corey, G. Ralph Chu, Vivian H. Clara, Liliana Sanchez, Marisa Nacinovich, Francisco Fernandez Oses, Pablo Ronderos, Ricardo Sucari, Adriana Thierer, Jorge Casabe, Jose Cortes, Claudia Altclas, Javier Kogan, Silvia Spelman, Denis Athan, Eugene Harris, Owen Kennedy, Karina Tan, Ren Gordon, David Papanicolas, Lito Eisen, Damon Grigg, Leeanne Street, Alan Korman, Tony Kotsanas, Despina Dever, Robyn Jones, Phillip Konecny, Pam Lawrence, Richard Rees, David Ryan, Suzanne Feneley, Michael P. Harkness, John Jones, Phillip Ryan, Suzanne Jones, Phillip Ryan, Suzanne Jones, Phillip Post, Jeffrey Reinbott, Porl Ryan, Suzanne Gattringer, Rainer Wiesbauer, Franz Andrade, Adriana Ribas Passos de Brito, Ana Claudia Guimaraes, Armenio Costa Grinberg, Max Mansur, Alfredo Jose Siciliano, Rinaldo Focaccia Varejao Strabelli, Tania Mara Campos Vieira, Marcelo Luiz de Medeiros Tranchesi, Regina Aparecida Paiva, Marcelo Goulart Fortes, Claudio Querido Ramos, Auristela de Oliveira Ferraiuoli, Giovanna Golebiovski, Wilma Lamas, Cristiane Santos, Marisa Weksler, Clara Karlowsky, James A. Keynan, Yoav Morris, Andrew M. Rubinstein, Ethan Jones, Sandra Braun Garcia, Patricia Cereceda, M. Fica, Alberto Mella, Rodrigo Montagna Barsic, Bruno Bukovski, Suzana Krajinovic, Vladimir Pangercic, Ana Rudez, Igor Vincelj, Josip Freiberger, Tomas Pol, Jiri Zaloudikova, Barbora Ashour, Zainab El Kholy, Amani Mishaal, Marwa Rizk, Hussien Aissa, Neijla Alauzet, Corentine Alla, Francois Campagnac, Catherine Doco-Lecompte, Thanh Selton-Suty, Christine Casalta, Jean-Paul Fournier, Pierre-Edouard Habib, Gilbert Raoult, Didier Thuny, Franck Delahaye, Francois Delahaye, Armelle Vandenesch, Francois Donal, Erwan Donnio, Pierre Yves Michelet, Christian Revest, Matthieu Tattevin, Pierre Violette, Jeremie Chevalier, Florent Jeu, Antoine Dan Rusinaru Sorel, Claire Tribouilloy, Christophe Bernard, Yvette Chirouze, Catherine Hoen, Bruno Leroy, Joel Plesiat, Patrick Naber, Christoph Neuerburg, Carl Mazaheri, Bahram Naber, Christoph Neuerburg, Carl Athanasia, Sofia Giannitsioti, Efthymia Mylona, Elena Paniara, Olga Papanicolaou, Konstantinos Pyros, John Skoutelis, Athanasios Sharma, Gautam Francis, Johnson Nair, Lathi Thomas, Vinod Venugopal, Krishnan Hannan, Margaret Hurley, John Gilon, Dan Israel, Sarah Korem, Maya Strahilevitz, Jacob Rubinstein, Ethan Strahilevitz, Jacob Tripodi, Marie Francoise Casillo, Roberta Cuccurullo, Susanna Dialetto, Giovanni Durante-Mangoni, Emanuele Irene, Mattucci Ragone, Enrico Utili, Riccardo Cecchi, Enrico De Rosa, Francesco Forno, Davide Imazio, Massimo Trinchero, Rita Tebini, Alessandro Grossi, Paolo Lattanzio, Mariangela Toniolo, Antonio Goglio, Antonio Raglio, Annibale Ravasio, Veronica Rizzi, Marco Suter, Fredy Carosi, Giampiero Magri, Silvia Signorini, Liana Baban, Tania Kanafani, Zeina Kanj, Souha S. Sfeir, Jad Yasmine, Mohamad Abidin, Imran Tamin, Syahidah Syed Martinez, Eduardo Rivera Nieto, Gabriel Israel Soto van der Meer, Jan T. M. Chambers, Stephen Holland, David Morris, Arthur Raymond, Nigel Read, Kerry Murdoch, David R. Dragulescu, Stefan Ionac, Adina Mornos, Cristian Butkevich, O. M. Chipigina, Natalia Kirill, Ozerecky Vadim, Kulichenko Vinogradova, Tatiana Edathodu, Jameela Halim, Magid Lum, Luh-Nah Tan, Ru-San Lejko-Zupanc, Tatjana Logar, Mateja Mueller-Premru, Manica Commerford, Patrick Commerford, Anita Deetlefs, Eduan Hansa, Cass Ntsekhe, Mpiko Almela, Manuel Armero, Yolanda Azqueta, Manuel Castaneda, Ximena Cervera, Carlos del Rio, Ana Falces, Carlos Garcia-de-la-Maria, Cristina Fita, Guillermina Gatell, Jose M. Marco, Francesc Mestres, Carlos A. Miro, Jose M. Moreno, Asuncion Ninot, Salvador Pare, Carlos Pericas, Joan Ramirez, Jose Rovira, Irene Sitges, Marta Anguera, Ignasi Font, Bernat Guma, Joan Raimon Bermejo, Javier Bouza, Emilio Garcia Fernandez, Miguel Angel Gonzalez-Ramallo, Victor Marin, Mercedes Munoz, Patricia Pedromingo, Miguel Roda, Jorge Rodriguez-Creixems, Marta Solis, Jorge Almirante, Benito Fernandez-Hidalgo, Nuria Tornos, Pilar de Alarcon, Aristides Parra, Ricardo Alestig, Eric Johansson, Magnus Olaison, Lars Snygg-Martin, Ulrika Pachirat, Orathai Pachirat, Pimchitra Pussadhamma, Burabha Senthong, Vichai Casey, Anna Elliott, Tom Lambert, Peter Watkin, Richard Eyton, Christina Klein, John L. Bradley, Suzanne Kauffman, Carol Bedimo, Roger Chu, Vivian H. Corey, G. Ralph Crowley, Anna Lisa Douglas, Pamela Drew, Laura Fowler, Vance G. Holland, Thomas Lalani, Tahaniyat Mudrick, Daniel Samad, Zaniab Sexton, Daniel Stryjewski, Martin Wang, Andrew Woods, Christopher W. Lerakis, Stamatios Cantey, Robert Steed, Lisa Wray, Dannah Dickerman, Stuart A. Bonilla, Hector DiPersio, Joseph Salstrom, Sara-Jane Baddley, John Patel, Mukesh Peterson, Gail Stancoven, Amy Afonso, Luis Kulman, Theresa Levine, Donald Rybak, Michael Cabell, Christopher H. Baloch, Khaula Chu, Vivian H. Corey, G. Ralph Dixon, Christy C. Fowler, Vance G. Harding, Tina Jones-Richmond, Marian Pappas, Paul Park, Lawrence P. Redick, Thomas Stafford, Judy Anstrom, Kevin Athan, Eugene Bayer, Arnold S. Cabell, Christopher H. Chu, Vivian H. Corey, G. Ralph Fowler, Vance G. Hoen, Bruno Karchmer, A. W. Miro, Jose M. Murdoch, David R. Sexton, Daniel J. Wang, Andrew Bayer, Arnold S. Cabell, Christopher H. Chu, Vivian Corey, G. Ralph Durack, David T. Phil, D. Eykyn, Susannah Fowler, Vance G. Hoen, Bruno Miro, Jose M. Moreillon, Phillipe Olaison, Lars Raoult, Didier Rubinstein, Ethan Sexton, Daniel J. |
| Título | HACEK Infective Endocarditis: Characteristics and Outcomes from a Large, Multi-National Cohort |
| Revista | Plos one |
| ISSN | 1932-6203 |
| Volumen | 8 |
| Número de publicación | 5 |
| Fecha de publicación | 2013 |
| Resumen | The HACEK organisms (Haemophilus species, Aggregatibacter species, Cardiobacterium hominis, Eikenella corrodens, and Kingella species) are rare causes of infective endocarditis (IE). The objective of this study is to describe the clinical characteristics and outcomes of patients with HACEK endocarditis (HE) in a large multi-national cohort. Patients hospitalized with definite or possible infective endocarditis by the International Collaboration on Endocarditis Prospective Cohort Study in 64 hospitals from 28 countries were included and characteristics of HE patients compared with IE due to other pathogens. Of 5591 patients enrolled, 77 (1.4%) had HE. HE was associated with a younger age (47 vs. 61 years; p < 0.001), a higher prevalence of immunologic/vascular manifestations (32% vs. 20%; p < 0.008) and stroke (25% vs. 17% p = 0.05) but a lower prevalence of congestive heart failure (15% vs. 30%; p = 0.004), death in-hospital (4% vs. 18%; p = 0.001) or after 1 year follow-up (6% vs. 20%; p = 0.01) than IE due to other pathogens (n = 5514). On multivariable analysis, stroke was associated with mitral valve vegetations (OR 3.60; CI 1.34-9.65; p < 0.01) and younger age (OR 0.62; CI 0.49-0.90; p < 0.01). The overall outcome of HE was excellent with the in-hospital mortality (4%) significantly better than for non-HE (18%; p < 0.001). Prosthetic valve endocarditis was more common in HE (35%) than non-HE (24%). The outcome of prosthetic valve and native valve HE was excellent whether treated medically or with surgery. Current treatment is very successful for the management of both native valve prosthetic valve HE but further studies are needed to determine why HE has a predilection for younger people and to cause stroke. The small number of patients and observational design limit inferences on treatment strategies. Self selection of study sites limits epidemiological inferences. |
| Derechos | acceso restringido |
| DOI | 10.1371/journal.pone.0063181 |
| Enlace | |
| Id de publicación en WoS | WOS:000319107900026 |
| Tema ODS | 03 Good Health and Well-being |
| Tema ODS español | 03 Salud y bienestar |
| Tipo de documento | artículo |