Experimental Analyses Emphasize the Stability of the Meisenheimer Complex in a S<sub>N</sub>Ar Reaction Toward Trends in Reaction Pathways

Campodonico, Paola R.

Pontificia Universidad Católica de Chile

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Campodonico, Paola R. Olivares, Belen Tapia, Ricardo A.

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The mechanism of SNAr reactions between 2-chloro-5-nitropyrimidine with primary and secondary alicyclic amines, respectively, have been studied by kinetic measurements. The kinetic data obtained in aqueous media opens a controversial discussion based on Bronsted-type plots analysis. The first approach based on the kinetic data reveals a non-catalyzed pathway. Then, the subtlety of the mathematical treatment of the kinetic data is discussed over a concerted or stepwise mechanism, respectively.

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Autor	Campodonico, Paola R. Olivares, Belen Tapia, Ricardo A.
Título	Experimental Analyses Emphasize the Stability of the Meisenheimer Complex in a S<sub>N</sub>Ar Reaction Toward Trends in Reaction Pathways
Revista	Frontiers in chemistry
ISSN	2296-2646
Volumen	8
Fecha de publicación	2020
Resumen	The mechanism of SNAr reactions between 2-chloro-5-nitropyrimidine with primary and secondary alicyclic amines, respectively, have been studied by kinetic measurements. The kinetic data obtained in aqueous media opens a controversial discussion based on Bronsted-type plots analysis. The first approach based on the kinetic data reveals a non-catalyzed pathway. Then, the subtlety of the mathematical treatment of the kinetic data is discussed over a concerted or stepwise mechanism, respectively.
Derechos	acceso restringido
Agencia financiadora	FONDECYT
DOI	10.3389/fchem.2020.00583
Enlace	https://doi.org/10.3389/fchem.2020.00583 https://repositorio.uc.cl/handle/11534/100499
Id de publicación en WoS	WOS:000555781600001
Palabra clave	SNAr reaction reaction mechanism Bronsted-type plots border mechanisms Meisenheimer complex
Tema ODS	03 Good Health and Well-being
Tema ODS español	03 Salud y bienestar
Tipo de documento	artículo