Cellular immune responses in amniotic fluid of women with a sonographic short cervix
link https://doi.org/10.1515/jpm-2020-0037account_box Galaz, Joseaccount_box Romero, Robertoaccount_box Xu, Yiaccount_box Miller, Derekaccount_box Levenson, Dustynaccount_box Para, Robertaccount_box Varrey, Aneeshaaccount_box Hsu, Richardaccount_box Tong, Annaaccount_box Hassan, Sonia S.account_box Hsu, Chaur-Dongaccount_box Gomez-Lopez, Nardhy
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Objectives: A sonographic short cervix is one of the strongest predictors of preterm delivery. However, the cellular immune composition of amniotic fluid in women with a short cervix has not yet been described. Herein, we determined cellular and soluble immune responses in amniotic fluid from pregnant women with a mid-trimester asymptomatic short cervix.
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| Autor | Galaz, Jose Romero, Roberto Xu, Yi Miller, Derek Levenson, Dustyn Para, Robert Varrey, Aneesha Hsu, Richard Tong, Anna Hassan, Sonia S. Hsu, Chaur-Dong Gomez-Lopez, Nardhy |
| Título | Cellular immune responses in amniotic fluid of women with a sonographic short cervix |
| Revista | Journal of perinatal medicine |
| ISSN | 0300-5577 |
| ISSN electrónico | 1619-3997 |
| Volumen | 48 |
| Número de publicación | 7 |
| Página inicio | 665 |
| Página final | 676 |
| Fecha de publicación | 2020 |
| Resumen | Objectives: A sonographic short cervix is one of the strongest predictors of preterm delivery. However, the cellular immune composition of amniotic fluid in women with a short cervix has not yet been described. Herein, we determined cellular and soluble immune responses in amniotic fluid from pregnant women with a mid-trimester asymptomatic short cervix. Methods: Amniotic fluid samples (n=77) were collected from asymptomatic women with a cervical length between 15 and 25 mm (n=36, short cervix) or <15 mm (n=41, severely short cervix) diagnosed by ultrasound. Flow cytometry and multiplex measurement of cytokines/chemokines were performed. Results: (1) The cellular immune composition of amniotic fluid did not differ between women with a severely short cervix (<= 15 mm) and those with a short cervix 15-25 mm; (2) amniotic fluid concentrations of multiple cytokines/chemokines were higher in women with a severely short cervix (<= 15 mm) than in those with a short cervix 15-25 mm; (3) the cellular immune composition of amniotic fluid did not differ between women with a severely short cervix (<= 15 mm) who ultimately underwent preterm delivery and those who delivered at term; and (4) amniotic fluid concentrations of IL-2, but not other immune mediators, were increased in women with a severely short cervix (<= 15 mm) who ultimately delivered preterm compared to those who delivered at term. Conclusions: Women with a severely short cervix (<= 15 mm) have increased concentrations of pro-inflammatory mediators in the amniotic cavity; yet, these do not translate to changes in the cellular immune response. |
| Derechos | acceso restringido |
| DOI | 10.1515/jpm-2020-0037 |
| Enlace | |
| Id de publicación en WoS | WOS:000573921700004 |
| Palabra clave | amniotic fluid cytoldne chemokine immune cell intra-amniotic inflammation preterm |
| Tema ODS | 03 Good Health and Well-being 05 Gender Equality |
| Tema ODS español | 03 Salud y bienestar 05 Igualdad de género |
| Tipo de documento | artículo |