Seminal plasma nerve growth factor signaling on the reproductive physiology of female llamas

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dc.contributor.authorPaiva, Luis
dc.contributor.authorSilva, Mauricio
dc.contributor.authorCarrasco, Rodrigo
dc.contributor.authorRatto, Vicente
dc.contributor.authorGoicochea, Jose
dc.contributor.authorRatto, Marcelo
dc.date.accessioned2024-01-10T13:45:25Z
dc.date.available2024-01-10T13:45:25Z
dc.date.issued2022
dc.description.abstractThe ovulation mechanism is one of the fascinating physiological processes in reproductive biology in mammals. From the reproductive point of view, the species have been classified as spontaneous or induced ovulators. Although the release of GnRH followed by the preovulatory LH surge is shared between both types of ovulation, the stimulus to initiate GnRH release varies between both categories. In spontaneous ovulators, ovulation depends on the systemic concentration of ovarian steroids, however, in induced ovulators, different stimuli such as copulation, environmental, and social cues can facilitate or induce ovulation regardless of the increases in systemic estradiol concentration. In this review, we document evidence that a male-derived protein is the main factor responsible for inducing ovulation and also modulating the ovarian function in the domestic South American camelid, the llama. The neurotrophin beta-Nerve Growth Factor (beta-NGF) is the principal factor present in the semen of llamas responsible for inducing ovulation in this species. After the intrauterine deposit of semen during mating, beta-NGF is absorbed through the endometrium to reach the circulatory system, where it reaches the hypothalamus and stimulates GnRH release. The potential site of action of this neurotrophin at the brain has not been elucidated, however, hypotheses are raised that the factor may cross the blood-brain barrier and stimulate upstream neuronal networks that lead to the stimulation of GnRH-secreting neurons. It is possible that beta-NGF could be sensed at the median eminence without crossing the blood-brain barrier. Finally, it has been observed that this factor is not only a powerful stimulator of ovulation but also has a luteotrophic effect, resulting in the development of a corpus luteum capable of secreting more progesterone when compared to other ovulation-stimulating analogues.
dc.fuente.origenWOS
dc.identifier.doi10.1590/1984-3143-AR2022-0116
dc.identifier.eissn1984-3143
dc.identifier.issn1806-9614
dc.identifier.urihttps://doi.org/10.1590/1984-3143-AR2022-0116
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/79030
dc.identifier.wosidWOS:000963960700001
dc.information.autorucInterdisciplinarias; Paiva Maldonado, Luis Alberto; S/I; 1248188
dc.issue.numero4
dc.language.isoen
dc.nota.accesoSin adjunto
dc.publisherBRAZILIAN COLL ANIMAL REPRODUCTION
dc.revistaANIMAL REPRODUCTION
dc.rightsregistro bibliográfico
dc.subjectsemen
dc.subjectovulation -inducing factor
dc.subjectcamelids
dc.subjectGnRH
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleSeminal plasma nerve growth factor signaling on the reproductive physiology of female llamas
dc.typeartículo
dc.volumen19
sipa.codpersvinculados1248188
sipa.indexWOS
sipa.trazabilidadCarga SIPA;09-01-2024
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